9330101J02Rik Inhibitors
Chemical inhibitors of cilia and flagella associated protein 46 involve a variety of mechanisms to disrupt its function. Aurintricarboxylic acid, by inhibiting nucleic acid enzymes, can prevent the proper assembly or functioning of this protein, as the RNA processing and translation machinery necessary for its expression or functionality is disrupted. Tubulozole targets the structural integrity of cilia by inhibiting tubulin polymerization, which is essential for the proper function and maintenance of cilia where cilia and flagella associated protein 46 operates. Similarly, Nocodazole's destabilization of microtubules can impair the trafficking and function of the protein within cilia. Cytochalasin D and Latrunculin A both disrupt the actin cytoskeleton, a network vital for the correct localization and function of cilia and flagella associated protein 46. Cytochalasin D disorganizes actin filaments, while Latrunculin A prevents polymerization by binding to actin monomers.
Colchicine and Colcemid bind to tubulin, preventing microtubule polymerization which is a crucial process for cilia formation and the function of cilia and flagella associated protein 46. In contrast, Taxol stabilizes microtubules too rigidly, which can inhibit the dynamic restructuring necessary for the protein to support ciliary structure. Dynein inhibitors, indicated by the CAS number 123312-89-0, directly affect the motor proteins required for the trafficking of the protein to or within the cilia. Furthermore, Swinholide A severs actin filaments, preventing their polymerization and thereby likely inhibiting the function of the protein by disrupting the actin structure. Griseofulvin impairs microtubule dynamics, which is essential for the localization and function of cilia and flagella associated protein 46 within cilia. Lastly, harmine targets DYRK1A, a kinase that modulates proteins associated with microtubule organization, and by doing so, it can alter the phosphorylation state and function of proteins, including cilia and flagella associated protein 46.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Aurintricarboxylic Acid | 4431-00-9 | sc-3525 sc-3525A sc-3525B sc-3525C | 100 mg 1 g 5 g 10 g | $20.00 $32.00 $48.00 $94.00 | 13 | |
Inhibits nucleic acid enzymes which could prevent the assembly or function of cilia and flagella associated protein 46 by disrupting the RNA processing or translation machinery necessary for its expression or function. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Disrupts actin filament organization; since cilia and flagella associated protein 46 is involved in cilia function and structure, disruption of the actin network can inhibit its proper localization or function. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Destabilizes microtubules, which could impair the trafficking and function of cilia and flagella associated protein 46 within cilia by disrupting the microtubule network required for its operation. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Binds to actin monomers and inhibits polymerization, which can disrupt cytoskeletal dynamics and potentially inhibit the proper positioning or function of cilia and flagella associated protein 46 within ciliary structures. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Binds tubulin and inhibits microtubule polymerization, which could inhibit the function of cilia and flagella associated protein 46 by disrupting microtubule dynamics that are critical for ciliary function. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Stabilizes microtubules, which could paradoxically inhibit the dynamic restructuring of microtubules required for cilia function and thus inhibit the role of cilia and flagella associated protein 46 in maintaining ciliary structure. | ||||||
Colcemid | 477-30-5 | sc-202550A sc-202550 sc-202550B sc-202550C sc-202550D sc-202550E | 1 mg 5 mg 10 mg 50 mg 100 mg 500 mg | $68.00 $162.00 $318.00 $947.00 $1893.00 $6840.00 | 7 | |
Binds to tubulin and inhibits microtubule assembly, which could inhibit the function of cilia and flagella associated protein 46 by preventing proper cilia formation and maintenance. | ||||||
Swinholide A, Theonella swinhoei | 95927-67-6 | sc-205914 | 10 µg | $135.00 | ||
Severs actin filaments and prevents polymerization, which could inhibit the function of cilia and flagella associated protein 46 by disrupting the actin cytoskeleton critical for ciliary structure and function. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $85.00 $220.00 $598.00 | 4 | |
Disrupts microtubule function, which could inhibit the function of cilia and flagella associated protein 46 by interfering with microtubule dynamics necessary for its localization and function within cilia. | ||||||
Harmine | 442-51-3 | sc-202644 sc-202644A sc-202644B sc-202644C sc-202644D sc-202644E sc-202644F | 250 mg 500 mg 1 g 10 g 50 g 100 g 500 g | $53.00 $104.00 $126.00 $551.00 $1467.00 $2611.00 $11455.00 | 2 | |
Inhibits DYRK1A, a kinase that phosphorylates proteins associated with microtubule organization; by inhibiting this kinase, the phosphorylation state and function of proteins including cilia and flagella associated protein 46 could be inhibited. | ||||||