5430416O09Rik Activators
Chemical activators of small regulatory polypeptide of amino acid response can be understood through their interaction with various cellular signaling pathways, particularly those associated with amino acid sensing and the mTOR pathway. Amino acids themselves, such as leucine, arginine, methionine, lysine, histidine, phenylalanine, tryptophan, and isoleucine, serve as primary examples of molecules that activate the mTOR pathway. This activation is crucial, as mTOR serves as a central regulator for cell growth and metabolism, responding to nutrient availability. When these amino acids are abundant, they activate the mTOR complex, which in turn activates the small regulatory polypeptide of amino acid response. This activation process is a critical part of the cellular adaptive response, facilitating the utilization of available amino acids for protein synthesis and other metabolic processes.
Besides amino acids, certain non-amino acid compounds also play a role in activating the small regulatory polypeptide of amino acid response. For instance, spermidine, known for its role in activating autophagy, can indirectly activate the protein by modulating the mTOR pathway activity in response to nutrient availability. Similarly, beta-hydroxy beta-methylbutyric acid (HMB) activates mTORC1 signaling, which in turn activates the small regulatory polypeptide of amino acid response. This indicates a broader scope of nutrient sensing beyond amino acids, where the availability of different molecules can influence the activity of the protein. Furthermore, essential minerals like zinc, represented by zinc sulfate, and magnesium, represented by magnesium sulfate, can also activate the mTOR pathway. The presence of these minerals is detected by cells and triggers a cascade of events, including the activation of the small regulatory polypeptide of amino acid response, showcasing the protein's role in the broader context of cellular nutrient sensing and response mechanisms.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
L-Leucine | 61-90-5 | sc-364173 sc-364173A | 25 g 100 g | $21.00 $61.00 | ||
Leucine activates the mammalian target of rapamycin (mTOR) pathway, which can lead to the downstream activation of the small regulatory polypeptide of amino acid response by promoting amino acid sensing and protein synthesis. | ||||||
L-Arginine | 74-79-3 | sc-391657B sc-391657 sc-391657A sc-391657C sc-391657D | 5 g 25 g 100 g 500 g 1 kg | $20.00 $30.00 $60.00 $215.00 $345.00 | 2 | |
Arginine activates the mTOR signaling pathway which is known to facilitate the activation of the small regulatory polypeptide of amino acid response, thus promoting protein synthesis in response to amino acid availability. | ||||||
DL-Methionine | 59-51-8 | sc-397777 | 100 g | $44.00 | ||
Methionine can activate the amino acid response pathway through the mTORC1 complex, thereby influencing the small regulatory polypeptide of amino acid response to modulate its activity in response to methionine levels. | ||||||
L-Lysine | 56-87-1 | sc-207804 sc-207804A sc-207804B | 25 g 100 g 1 kg | $93.00 $258.00 $519.00 | ||
Lysine's role in activating mTORC1 can indirectly lead to the activation of the small regulatory polypeptide of amino acid response, which plays a part in the cellular response to amino acid availability. | ||||||
L-Phenylalanine | 63-91-2 | sc-394058 sc-394058A sc-394058B | 100 g 500 g 1 kg | $112.00 $457.00 $679.00 | 1 | |
Phenylalanine can activate the mTOR pathway, which includes the small regulatory polypeptide of amino acid response as a downstream effector involved in the amino acid sensing and signaling. | ||||||
L-Tryptophan | 73-22-3 | sc-280888 sc-280888A sc-280888B | 100 g 1 kg 5 kg | $126.00 $357.00 $1760.00 | ||
Tryptophan activates the general control nonderepressible 2 (GCN2) kinase pathway, which can then activate the small regulatory polypeptide of amino acid response due to amino acid starvation conditions. | ||||||
L-Isoleucine | 73-32-5 | sc-396706 sc-396706A | 25 g 100 g | $24.00 $118.00 | ||
Isoleucine is another amino acid that can activate the mTOR pathway, subsequently activating the small regulatory polypeptide of amino acid response to promote cellular responses to amino acid availability. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $56.00 $595.00 $173.00 | ||
Spermidine has been shown to activate autophagy through mTOR inhibition, which can indirectly activate the small regulatory polypeptide of amino acid response as part of the autophagic response to nutrient availability. | ||||||
β-Hydroxyisovaleric acid | 625-08-1 | sc-235338 | 5 g | $490.00 | ||
β-Hydroxyisovaleric acid activates the mTORC1 signaling pathway, which in turn can activate the small regulatory polypeptide of amino acid response, integrating signals of nutrient availability. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc sulfate can activate the mTOR pathway, which would then activate the small regulatory polypeptide of amino acid response as part of the cellular adaptive response to varying zinc ion concentrations. | ||||||