53BP1 Inhibitors
The class of compounds known as 53BP1 inhibitors encompasses a diverse array of small molecules targeting various components of the DNA damage response pathway. These inhibitors exert their effects by selectively modulating specific kinases involved in signaling cascades crucial for the cellular recognition and repair of DNA lesions. Nu6027, AZD7648, and VE-821 target DNA-PK and ATM kinases, indirectly impacting 53BP1 by altering its recruitment to damaged DNA sites. Mirin disrupts the MRN complex, influencing the dynamics of 53BP1 in response to DNA double-strand breaks. KU-55933 inhibits ATM kinase, indirectly modulating 53BP1-mediated DNA repair.
Additionally, compounds like CC-115, PFM01, and B02 interfere with cell cycle progression through inhibition of mTOR, WEE1, and PLK1, respectively. These compounds indirectly influence 53BP1 by altering the cellular response to DNA damage and modulating its function during mitosis. CLK family kinase inhibitor CGK733 and checkpoint kinase inhibitors (CAY10576 and CP466722) impact alternative splicing events and checkpoint regulation, respectively, altering the cellular response to genotoxic stress and influencing 53BP1 function in DNA repair processes. Rigosertib, a multi-kinase inhibitor, affects PI3K/Akt and PLK1, indirectly modulating 53BP1 during mitosis and DNA double-strand break repair.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
NU6027 | 220036-08-8 | sc-215591 | 10 mg | $156.00 | 1 | |
Nu6027 is a selective DNA-dependent protein kinase (DNA-PK) inhibitor. It influences the DNA damage response pathway by specifically targeting and inhibiting DNA-PK, indirectly modulating 53BP1, which is involved in the repair of DNA double-strand breaks. | ||||||
MRN-ATM Pathway Inhibitor, Mirin | 299953-00-7 | sc-203144 | 10 mg | $141.00 | 4 | |
Mirin is an Mre11 nuclease inhibitor that disrupts the Mre11-Rad50-Nbs1 (MRN) complex involved in DNA double-strand break repair. By inhibiting MRN, Mirin indirectly influences the recruitment and function of 53BP1 in the DNA damage repair pathway, altering the dynamics of cellular responses to DNA damage. | ||||||
VE 821 | 1232410-49-9 | sc-475878 | 10 mg | $360.00 | ||
VE-821 is a selective inhibitor of the ataxia telangiectasia mutated (ATM) kinase, a key regulator in the DNA damage response. Inhibition of ATM by VE-821 leads to indirect modulation of 53BP1, impacting its recruitment to damaged DNA sites and influencing the overall DNA repair pathway in response to genotoxic stress. | ||||||
ATM Kinase Inhibitor | 587871-26-9 | sc-202963 | 2 mg | $110.00 | 28 | |
KATM Kinase Inhibitor (U-55933) disrupts the ATM-mediated DNA damage response. Through inhibition of ATM, KU-55933 indirectly affects 53BP1, altering its dynamics in recognizing and repairing DNA double-strand breaks, and consequently influencing the cellular response to genotoxic insults. | ||||||
RAD51 Inhibitor B02 | 1290541-46-6 | sc-507533 | 10 mg | $95.00 | ||
B02 is a selective inhibitor of Polo-like kinase 1 (PLK1), a crucial regulator of mitotic progression. Inhibition of PLK1 by B02 indirectly affects 53BP1 by altering the normal cell cycle progression, impacting the cellular response to DNA damage, and modulating 53BP1 function during mitosis. | ||||||
ATM/ATR Kinase Inhibitor Inhibitor | 905973-89-9 | sc-202964 | 5 mg | $106.00 | 8 | |
CGK733 is a potent and selective inhibitor of CLK family kinases. Through CLK inhibition, CGK733 indirectly modulates 53BP1 by influencing alternative splicing events critical for DNA damage response gene expression, altering the cellular response to genotoxic stress, and impacting 53BP1 function in the context of DNA double-strand break repair. | ||||||
ON-01910 | 1225497-78-8 | sc-364556 sc-364556A | 5 mg 10 mg | $300.00 $700.00 | ||
Rigosertib is a multi-kinase inhibitor that affects multiple signaling pathways, including PI3K/Akt and PLK1. By targeting PLK1, Rigosertib indirectly modulates 53BP1 by influencing mitotic progression, altering the cellular response to DNA damage, and impacting the function of 53BP1 during mitosis and DNA double-strand break repair. | ||||||