4930547C10Rik Activators

Chemical activators of toporsl include a range of compounds that interact with DNA and DNA-modifying enzymes, eliciting a response that involves the activation of toporsl to facilitate DNA repair. Camptothecin operates by stabilizing the complex formed between DNA and topoisomerase I, resulting in an accumulation of DNA breaks that require toporsl's intervention. Topotecan, similarly, hinders the re-ligation function of topoisomerase I, leading to DNA damage that necessitates toporsl's repair activity. SN-38, the active derivative of irinotecan, also stabilizes the DNA-topoisomerase complex, creating a context in which toporsl's activity is needed.

Additionally, beta-Lapachone induces DNA damage through the generation of reactive oxygen species and the stabilization of topoisomerase I-DNA cleavable complexes, both circumstances that prompt the activation of toporsl. Indotecan and genistein, although through different mechanisms, result in DNA breaks that engage toporsl; indotecan by directly inhibiting topoisomerase I and genistein by inhibiting topoisomerase II, which can lead to aberrant recombination intermediates. Etoposide and teniposide target topoisomerase II, leading to DNA double-strand breaks that necessitate the activation of toporsl for repair. Ellipticine, amsacrine, mitoxantrone, and pixantrone are additional chemicals that intercalate into DNA or inhibit topoisomerase II, resulting in DNA damage that invokes the repair functions of toporsl. Each of these chemical activators, through their interaction with DNA or inhibition of topoisomerases, indirectly promote the activation of toporsl as it is crucial for the cellular process of DNA repair.