4930534B04Rik Inhibitors

The chemical class referred to as Cep128 Inhibitors consists of compounds with the capability to indirectly influence the function of the centrosomal protein Cep128. These chemicals are not direct antagonists of Cep128 but operate by modulating cellular mechanisms and structures that are crucial for the proper functioning of Cep128 within the cell. Nocodazole and Paclitaxel, for example, exert their effects on microtubule dynamics, a key component of the centrosome and mitotic spindle, to which Cep128 is fundamentally related. Disruption of microtubule dynamics by these agents can lead to a cascading effect that interferes with Cep128's role in spindle assembly and function.

Further to this, inhibitors like Roscovitine and Purvalanol A target CDKs, which are pivotal in cell cycle regulation, including centrosome duplication and maturation, processes that are likely to involve Cep128. Similarly, compounds such as BI 2536 and Centrinone interfere with proteins like Plk1 and PLK4, respectively, which are essential for centrosome and spindle function, thereby indirectly affecting the role of Cep128. Aurora kinase inhibitors such as ZM447439 and AZD1152-HQPA are included in this class because they disrupt chromosome alignment and segregation during mitosis, processes that are potentially mediated by Cep128.