2010007H12Rik Activators
Chemical activators of protein phosphatase 1, regulatory subunit 35 can modulate the protein's activity through various biochemical mechanisms. Forskolin acts directly on adenylate cyclase to increase levels of cyclic AMP within the cell, which subsequently activates protein kinase A (PKA). PKA then phosphorylates several substrates, including protein phosphatase 1, regulatory subunit 35, altering its conformation and interaction dynamics, thereby increasing its activity. Cyclic AMP follows a similar pathway, serving as a messenger to activate PKA and promote the phosphorylation and activation of protein phosphatase 1, regulatory subunit 35. Spermine, through its interactions with ion channels and modulation of kinase activity, also facilitates the activation of the protein by enhancing kinase-mediated phosphorylation.
On the other hand, several inhibitors of protein phosphatases, such as Calyculin A, Okadaic Acid, Tautomycin, Cantharidin, Microcystin-LR, Endothall, Fostriecin, and Rubratoxin B, indirectly contribute to the activation of protein phosphatase 1, regulatory subunit 35. These compounds inhibit the action of protein phosphatases 1 and 2A, leading to reduced phosphatase activity in the cell. The decreased phosphatase action results in an accumulation of phosphorylated proteins, which may include protein phosphatase 1, regulatory subunit 35. The cell responds to these changes by activating compensatory mechanisms to restore the balance of phosphorylation, leading to the activation of protein phosphatase 1, regulatory subunit 35. Zoledronic Acid, although primarily known for its inhibition of farnesyl pyrophosphate synthase, influences signaling pathways that can result in the increased activity of protein kinase A, which, in turn, can phosphorylate and activate protein phosphatase 1, regulatory subunit 35.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A is a potent inhibitor of protein phosphatases 1 and 2A. By inhibiting their phosphatase activity, it indirectly leads to increased phosphorylation levels of proteins, which could include protein phosphatase 1, regulatory subunit 35, resulting in its activation due to a compensatory feedback mechanism. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Similar to Calyculin A, Okadaic Acid inhibits protein phosphatases, especially PP2A. Its inhibition leads to the compensatory activation of protein phosphatase 1, regulatory subunit 35 due to the disruption of phosphatase-protein kinase balance in cells. | ||||||
Cantharidin | 56-25-7 | sc-201321 sc-201321A | 25 mg 100 mg | $89.00 $279.00 | 6 | |
Cantharidin is a natural toxin that inhibits the activity of protein phosphatases 1 and 2A. The inhibition increases the phosphorylation status of various proteins, potentially including protein phosphatase 1, regulatory subunit 35, thus activating it. | ||||||
Zoledronic acid, anhydrous | 118072-93-8 | sc-364663 sc-364663A | 25 mg 100 mg | $92.00 $256.00 | 5 | |
Zoledronic Acid is a bisphosphonate that inhibits farnesyl pyrophosphate synthase, leading to a reduction in prenylated proteins within the cell. This inhibition can increase the activity of protein kinase A through altered signaling pathways, which may activate protein phosphatase 1, regulatory subunit 35 by increased phosphorylation. | ||||||
Endothall | 145-73-3 | sc-201325 sc-201325A | 20 mg 100 mg | $49.00 $203.00 | 1 | |
Endothall disrupts protein phosphatase activity, which can lead to an activation of protein phosphatase 1, regulatory subunit 35 through feedback mechanisms intended to restore phosphorylation balance. | ||||||
Fostriecin | 87860-39-7 | sc-202160 | 50 µg | $265.00 | 9 | |
Fostriecin selectively inhibits PP2A and PP4, which could lead to activation of protein phosphatase 1, regulatory subunit 35 through increased phosphorylation levels due to reduced dephosphorylation activity. | ||||||
Spermine | 71-44-3 | sc-212953A sc-212953 sc-212953B sc-212953C | 1 g 5 g 25 g 100 g | $61.00 $196.00 $277.00 $901.00 | 1 | |
Spermine is known to interact with various ion channels and can modulate kinase activity. It could activate protein phosphatase 1, regulatory subunit 35 by promoting kinase activity that phosphorylates and activates the regulatory subunit. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $116.00 $179.00 $265.00 $369.00 $629.00 $1150.00 | ||
Cyclic AMP directly activates protein kinase A, which in turn can phosphorylate and promote the activation of protein phosphatase 1, regulatory subunit 35 by altering its binding affinities and interactions with other proteins. | ||||||