1700011H22Rik Activators
Izumo sperm-egg fusion protein 3 Activators comprise a spectrum of chemical compounds that enhance the functional activity of Izumo sperm-egg fusion protein 3 by modulating various signaling pathways. Forskolin, Sildenafil, and Epigallocatechin gallate (EGCG) elevate cAMP and cGMP levels, leading to the activation of PKA or PKG pathways, which are vital for sperm capacitation and the acrosome reaction, thereby potentially enhancing the fusogenic function of Izumo sperm-egg fusion protein 3. Similarly, Pentoxifylline and Rolipram, both phosphodiesterase inhibitors, andCilostamide, another PDE inhibitor, increase intracellular cAMP, which is known to regulate protein kinase A (PKA) and influence pathways that are likely to enhance Izumo sperm-egg fusion protein 3 activity, crucial for the binding and fusion of sperm to the oocyte. The inclusion of Zn2+ ions could also provide structural stabilization or modulate the ionic environment to favor Izumo sperm-egg fusion protein 3 functionality.
In addition to these, Y-27632, a ROCK inhibitor, and A23187, a calcium ionophore, indirectly act by altering cytoskeletal dynamics and increasing intracellular calcium, respectively, which are processes that can potentiate the activity of Izumo sperm-egg fusion protein 3 during sperm's preparation for fusion with the egg. Niflumic acid, by modulating chloride channels, might affect the ionic balance and membrane potential, which are known to play a role in sperm capacitation and acrosome reaction, thus possibly enhancing the function of Izumo sperm-egg fusion protein 3. Ouabain's inhibition of Na+/K+-ATPase might also contribute to modifications in sperm motility and ionic changes conducive to the activation of Izumo sperm-egg fusion protein 3. Collectively, these activators enhance the activity of Izumo sperm-egg fusion protein 3 through multifaceted biochemical pathways, each converging on the critical process of sperm-egg fusion without the need for upregulating its expression or direct activation.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc ions can act as allosteric modulators of various enzymes and ion channels, potentially enhancing the Izumo sperm-egg fusion protein 3 function by stabilizing its structure or by modulating the ionic environment during the acrosome reaction. | ||||||
L-Arginine | 74-79-3 | sc-391657B sc-391657 sc-391657A sc-391657C sc-391657D | 5 g 25 g 100 g 500 g 1 kg | $20.00 $30.00 $60.00 $215.00 $345.00 | 2 | |
L-Arginine is a precursor for nitric oxide (NO) synthesis. NO may improve Izumo sperm-egg fusion protein 3 activity by modulating sperm motility and capacitation through cGMP-mediated signaling pathways. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG can inhibit phosphodiesterases, leading to increased cAMP levels, which indirectly enhance Izumo sperm-egg fusion protein 3 activity via PKA signaling pathways that could be involved in the acrosome reaction. | ||||||
Pentoxifylline | 6493-05-6 | sc-203184 | 1 g | $20.00 | 3 | |
Pentoxifylline is a phosphodiesterase inhibitor that increases cAMP levels, which can indirectly augment Izumo sperm-egg fusion protein 3 function by enhancing sperm motility and capacitation. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a ROCK inhibitor; by inhibiting ROCK, it may bolster Izumo sperm-egg fusion protein 3 function by altering actin cytoskeleton dynamics, which is important for sperm motility and the acrosome reaction. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is another phosphodiesterase inhibitor that increases cAMP, potentially enhancing Izumo sperm-egg fusion protein 3 by activating PKA and modulating processes essential for sperm-egg fusion. | ||||||
Cilostamide (OPC 3689) | 68550-75-4 | sc-201180 sc-201180A | 5 mg 25 mg | $90.00 $350.00 | 16 | |
Cilostamide, a selective PDE3 inhibitor, increases cAMP levels, indirectly enhancing Izumo sperm-egg fusion protein 3 activity by influencing sperm capacitation and possibly the acrosome reaction. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is an ionophore that increases intracellular calcium levels; elevated calcium can activate pathways that enhance the function of Izumo sperm-egg fusion protein 3 during the acrosome reaction. | ||||||
Niflumic acid | 4394-00-7 | sc-204820 | 5 g | $31.00 | 3 | |
Niflumic acid, as a modulator of chloride channels, may influence the ionic balance and membrane potential, indirectly enhancing Izumo sperm-egg fusion protein 3 by affecting the acrosome reaction or sperm capacitation. | ||||||
Ouabain-d3 (Major) | sc-478417 | 1 mg | $506.00 | |||
Ouabain, by inhibiting Na+/K+-ATPase, may indirectly enhance Izumo sperm-egg fusion protein 3 function through modifications in sperm motility and the ionic environment during the fertilization process. | ||||||