1700007K09Rik Inhibitors
Chemical inhibitors of protein kinase activity can modulate the function of specific proteins by altering their phosphorylation state. Staurosporine is one such inhibitor that has a broad-spectrum effect on protein kinases, which can lead to the inhibition of multiple phosphorylation events in cellular signaling pathways. This inhibitory action can directly impact the function of proteins like 1700007K09Rik by preventing their phosphorylation and subsequent activation or inactivation, depending on the protein's role in the cell. Similarly, Bisindolylmaleimide I targets Protein Kinase C (PKC), a specific kinase that, when inhibited, can prevent the activation of proteins that rely on PKC for their phosphorylation. Such an inhibition can also affect 1700007K09Rik if its functional state is contingent on PKC-mediated phosphorylation.
LY294002 and Wortmannin are inhibitors that target the phosphoinositide 3-kinases (PI3K), a pivotal kinase in the regulation of various cellular functions. By inhibiting PI3K, these chemicals disrupt the PI3K/Akt signaling pathway, which can lead to the functional inhibition of proteins involved in this pathway, including 1700007K09Rik if it is a downstream target. On a different signaling axis, PD98059 and U0126 inhibit MEK1/2, which are key components of the MAPK/ERK pathway. Inhibition of MEK consequently prevents the activation of ERK and the phosphorylation of substrates involved in this pathway, which could include 1700007K09Rik. Similarly, SP600125, a JNK inhibitor, can suppress the activity of proteins that are regulated as part of the JNK signaling cascade. Additionally, Y-27632 acts upon Rho-associated protein kinase (ROCK), and its inhibitory effect on the Rho/ROCK pathway can lead to the modulation of protein functions that are dependent on signals from this kinase. Lastly, SB203580, which inhibits p38 MAP kinase, can alter the functional state of proteins like 1700007K09Rik if they play a role in the p38 MAPK-regulated response.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine can inhibit a broad range of protein kinases. If 1700007K09Rik is regulated by phosphorylation through kinase activity, staurosporine would inhibit this regulation by preventing the phosphorylation of 1700007K09Rik, leading to its functional inhibition. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
This chemical is a specific inhibitor of Protein Kinase C (PKC). By inhibiting PKC, it could prevent the phosphorylation and subsequent activation of downstream proteins. If 1700007K09Rik activity requires PKC-mediated phosphorylation, Bisindolylmaleimide I would functionally inhibit 1700007K09Rik by blocking this essential modification. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 inhibits phosphoinositide 3-kinases (PI3K). By blocking PI3K, it would halt the PI3K/Akt signaling pathway. If 1700007K09Rik function is dependent on signals propagated through this pathway, inhibition by LY294002 would result in the functional inhibition of 1700007K09Rik. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is another potent inhibitor of PI3K. It would prevent the activation of the PI3K/Akt pathway, which is essential for numerous cellular processes. Inhibition of this pathway by Wortmannin would lead to functional inhibition of 1700007K09Rik if it is a downstream effector of PI3K signaling. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits the mammalian target of rapamycin (mTOR) pathway. Inhibition of mTOR signaling can lead to the downregulation of several downstream cellular processes. Should 1700007K09Rik be involved in one of these processes, its functional activity would be inhibited by rapamycin. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
PP2 is an inhibitor of Src family tyrosine kinases. These kinases are involved in various signaling pathways, including those regulating cell proliferation and differentiation. If the activity of 1700007K09Rik is controlled by Src family kinases, PP2 would inhibit its function. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 inhibits MEK1/2, which are upstream of extracellular signal-regulated kinases (ERK). If 1700007K09Rik function is regulated by the MEK/ERK pathway, then inhibiting MEK with PD98059 would result in functional inhibition of 1700007K09Rik. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is another MEK inhibitor, which would block the activation of the ERK pathway. If 1700007K09Rik activity is dependent on ERK signaling, U0126 would inhibit its function. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK). If 1700007K09Rik is a downstream target in the JNK signaling pathway, inhibition by SP600125 would lead to its functional inhibition. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 inhibits Rho-associated protein kinase (ROCK). If 1700007K09Rik activity is mediated through the Rho/ROCK pathway, inhibition of ROCK by Y-27632 would result in functional inhibition of 1700007K09Rik. | ||||||