0710008K08Rik Activators
0710008K08Rik Activators encompass a variety of chemical compounds that synergistically enhance the functional activity of 0710008K08Rik through intricate cellular signaling pathways. Compounds such as Forskolin and IBMX exert their effects by elevating intracellular levels of cAMP, which subsequently activates PKA. This kinase, in turn, phosphorylates various substrates that can directly or indirectly enhance the function of 0710008K08Rik, ensuring its sustained activity. Similarly, Epigallocatechin gallate and Genistein influence the activity of 0710008K08Rik by inhibiting specific kinases, thereby reducing competitive phosphorylation events and promoting pathways favorable to 0710008K08Rik activation. The direct PKC activator PMA and the sphingolipid Sphingosine-1-phosphate further potentiate this effect bymodulating the phosphorylation status of interacting or regulatory proteins, enhancing the functional state of 0710008K08Rik.
In addition to modulation through kinase pathways, the activity of 0710008K08Rik is influenced by the cellular balance of phosphorylation states as manipulated by inhibitors like LY294002, U0126, and SB203580. These compounds indirectly enhance 0710008K08Rik's activity by inhibiting PI3K, MEK, and p38 MAPK, respectively, which could otherwise impose repressive effects on the pathways involving 0710008K08Rik. The calcium-mediated signaling is another axis through which 0710008K08Rik activators operate; A23187 and Thapsigargin both increase intracellular calcium concentrations, triggering calcium-dependent kinases and phosphatases that bolster 0710008K08Rik's activity. Staurosporine, albeit a general kinase inhibitor, can at specific concentrations preferentially relieve negative regulatory kinases of 0710008K08Rik. Through these multifaceted mechanisms, each activator contributes to the enhanced functional landscape of 0710008K08Rik, carving a cellular milieu that favors its activity without directly increasing its expression or requiring direct ligand binding for activation.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-specific inhibitor of phosphodiesterases, which prevents the breakdown of cAMP and cGMP, leading to their accumulation. This can enhance the function of 0710008K08Rik by maintaining PKA activation and sustaining phosphorylation states that promote 0710008K08Rik activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin gallate is a polyphenol that inhibits certain kinases, which might lead to reduced competitive phosphorylation on proteins that regulate the function of 0710008K08Rik, thereby enhancing its activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC), which can phosphorylate proteins that are upstream or directly interact with 0710008K08Rik, thereby enhancing its functional activity. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate acts on its receptors to activate downstream kinases such as PKC, which could lead to the phosphorylation of regulatory proteins that enhance the activity of 0710008K08Rik. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that can alter signaling balance in cells, potentially attenuating negative regulatory pathways and thus indirectly enhancing the activity of 0710008K08Rik by lifting inhibitions. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor that may enhance the activity of 0710008K08Rik by altering the phosphorylation state of proteins that interact with or regulate 0710008K08Rik, thereby modulating its function. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular calcium levels, which can activate calcium-dependent kinases and phosphatases that modulate the function of 0710008K08Rik, leading to its activation. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that may enhance the activity of 0710008K08Rik by reducing competitive tyrosine kinase signaling, allowing pathways involving 0710008K08Rik to be more active. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a broad-spectrum kinase inhibitor that, at low concentrations, may selectively enhance the activity of 0710008K08Rik by inhibiting kinases that negatively regulate its function. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor that leads to increased cytosolic calcium levels, which can indirectly enhance the activity of 0710008K08Rik through calcium-dependent signaling pathways. | ||||||