0610038D11Rik Inhibitors
Chemical inhibitors of protein 0610038D11Rik employ various mechanisms to modulate its activity by altering phosphorylation processes. Bisindolylmaleimide I, functioning as a protein kinase C (PKC) inhibitor, can prevent PKC from phosphorylating 0610038D11Rik, leading to a decrease in its activity. Similarly, Gö 6983, another PKC inhibitor, can also suppress the activity of 0610038D11Rik by inhibiting the kinase responsible for its activation. LY333531 targets the beta isoforms of PKC, and by doing so, can also hinder the phosphorylation and subsequent activity of 0610038D11Rik. Genistein, as a tyrosine kinase inhibitor, can affect the phosphorylation status of 0610038D11Rik by inhibiting the enzymes responsible for adding phosphate groups to tyrosine residues, a modification that often regulates protein function and interactions.
Triciribine and Wortmannin, inhibitors of AKT and PI3K respectively, act upstream in the signaling pathway and can lead to reduced phosphorylation of 0610038D11Rik by preventing the activation of these kinases. Y-27632, which inhibits Rho-associated protein kinase (ROCK), can decrease the activity of 0610038D11Rik if ROCK is involved in phosphorylating 0610038D11Rik or if it plays a role in a shared signaling pathway. PD168393, an irreversible inhibitor of EGFR tyrosine kinase, can suppress the downstream signaling that might activate 0610038D11Rik. SB431542, by inhibiting the TGF-beta receptor, can interfere with a pathway that 0610038D11Rik may be a part of, thus impeding its function. SP600125, as an inhibitor of JNK, and SL327, a MEK inhibitor, can both prevent the activation of MAPK pathway components, which may include 0610038D11Rik. GW5074, targeting Raf-1 kinase, can also lead to diminished activity of 0610038D11Rik by inhibiting the MAPK/ERK signaling pathway, where Raf-1 is a key player. Each chemical's mode of action is distinct, but they all converge on the regulation of 0610038D11Rik by modifying its phosphorylation state directly or indirectly through various signaling cascades.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
This compound is a protein kinase C inhibitor. Considering that protein kinase C can phosphorylate various substrates including 0610038D11Rik, inhibition of this kinase can lead to reduced phosphorylation and thus inhibition of 0610038D11Rik activity. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor. Since tyrosine kinase enzymes can catalyze the phosphorylation of proteins like 0610038D11Rik, the inhibition of these kinases by Genistein can result in the functional inhibition of 0610038D11Rik. | ||||||
Triciribine | 35943-35-2 | sc-200661 sc-200661A | 1 mg 5 mg | $102.00 $138.00 | 14 | |
Triciribine is an AKT inhibitor. By preventing AKT activation, it can inhibit the phosphorylation of downstream targets, potentially including 0610038D11Rik, thereby inhibiting 0610038D11Rik’s activity. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is an inhibitor of ROCK (Rho-associated protein kinase). ROCK can phosphorylate a wide range of substrates, potentially including 0610038D11Rik, and its inhibition can lead to decreased activity of 0610038D11Rik. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
SB431542 is an inhibitor of the TGF-beta receptor. If 0610038D11Rik is part of the TGF-beta signaling pathway, inhibition by SB431542 could lead to the functional inhibition of 0610038D11Rik. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK (c-Jun N-terminal kinase). If JNK phosphorylates 0610038D11Rik or is involved in a pathway with 0610038D11Rik, inhibition by SP600125 could reduce 0610038D11Rik activity. | ||||||
GW 5074 | 220904-83-6 | sc-200639 sc-200639A | 5 mg 25 mg | $106.00 $417.00 | 10 | |
GW5074 is an inhibitor of Raf-1 kinase. With Raf-1 being a part of the MAPK/ERK pathway, its inhibition by GW5074 could lead to the functional inhibition of downstream proteins like 0610038D11Rik. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $103.00 $293.00 $465.00 | 15 | |
Gö 6983 is a pan-protein kinase C inhibitor. If 0610038D11Rik is regulated by protein kinase C, Gö 6983 inhibition could result in decreased 0610038D11Rik activity. | ||||||
SL-327 | 305350-87-2 | sc-200685 sc-200685A | 1 mg 10 mg | $107.00 $332.00 | 7 | |
SL327 is an inhibitor of MEK, which is upstream of ERK in the MAPK pathway. Inhibition of MEK by SL327 would reduce ERK activity which could in turn inhibit the activity of 0610038D11Rik if it is part of the ERK pathway. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a PI3K inhibitor. By inhibiting PI3K, it can prevent the activation of AKT and subsequent phosphorylation of downstream proteins, which may include 0610038D11Rik, thus inhibiting 0610038D11Rik function. | ||||||