Molecular structure of GW 5074, CAS Number: 220904-83-6
GW 5074 (CAS 220904-83-6)
See product citations (10)
Alternate Names:
3-(3,5-Dibromo-4-hydroxybenzyliden)-5-iodo-1,3-dihydroindol-2-one
Application:
GW 5074 is an inhibitor of c-Raf-1 kinase and PMA-mediated activation of ERK1/2
CAS Number:
220904-83-6
Purity:
≥98%
Molecular Weight:
520.94
Molecular Formula:
C15H8Br2INO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
GW 5074 is a research chemical of significant interest due to its role as an inhibitor of the protein kinase C-Raf (also known as c-Raf-1). This compound is extensively used in cellular and molecular biology studies to explore the Raf/MEK/ERK signaling pathway, which is implicated in the regulation of cell division, survival, and differentiation. By inhibiting C-Raf, GW 5074 allows researchers to investigate the consequences of blocking this pathway, providing insights into the fundamental understanding of cell signaling mechanisms. Additionally, GW 5074 is used to study its effects on neurotrophic factors and neuronal survival, contributing to the broader realm of neurobiology research. The compound′s ability to modulate kinase activity makes it a useful probe in the study of signal transduction and kinase-regulated processes within cells.
GW 5074 (CAS 220904-83-6) References
- The discovery of potent cRaf1 kinase inhibitors. | Lackey, K., et al. 2000. Bioorg Med Chem Lett. 10: 223-6. PMID: 10698440
- Peptidoglycan induces nuclear factor-kappaB activation and cyclooxygenase-2 expression via Ras, Raf-1, and ERK in RAW 264.7 macrophages. | Chen, BC., et al. 2004. J Biol Chem. 279: 20889-97. PMID: 15007072
- The c-Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK-ERK and Akt-independent mechanism. | Chin, PC., et al. 2004. J Neurochem. 90: 595-608. PMID: 15255937
- Bradykinin B2 receptor mediates NF-kappaB activation and cyclooxygenase-2 expression via the Ras/Raf-1/ERK pathway in human airway epithelial cells. | Chen, BC., et al. 2004. J Immunol. 173: 5219-28. PMID: 15470067
- Phorbol 12-myristate 13-acetate upregulates cyclooxygenase-2 expression in human pulmonary epithelial cells via Ras, Raf-1, ERK, and NF-kappaB, but not p38 MAPK, pathways. | Chang, MS., et al. 2005. Cell Signal. 17: 299-310. PMID: 15567061
- Fibroblast growth factor-2 suppresses oridonin-induced L929 apoptosis through extracellular signal-regulated kinase-dependent and phosphatidylinositol 3-kinase-independent pathway. | Huang, J., et al. 2006. J Pharmacol Sci. 102: 305-13. PMID: 17116975
- Involvement of Ras/Raf-1/p44/42 MAPK in YC-1-induced cyclooxygenase-2 expression in human pulmonary epithelial cells. | Chang, MS., et al. 2009. Pharmacol Res. 60: 247-53. PMID: 19717011
- Protein farnesylation-dependent Raf/extracellular signal-related kinase signaling links to cytoskeletal remodeling to facilitate glucose-induced insulin secretion in pancreatic beta-cells. | Kowluru, A., et al. 2010. Diabetes. 59: 967-77. PMID: 20071600
- Disruption of angiogenesis and tumor growth with an orally active drug that stabilizes the inactive state of PDGFRbeta/B-RAF. | Murphy, EA., et al. 2010. Proc Natl Acad Sci U S A. 107: 4299-304. PMID: 20154271
- Analgesic potential of intrathecal farnesyl thiosalicylic acid and GW 5074 in vincristine-induced neuropathic pain in rats. | Jaggi, AS. and Singh, N. 2012. Food Chem Toxicol. 50: 1295-301. PMID: 22326968
- Intrathecal delivery of farnesyl thiosalicylic acid and GW 5074 attenuates hyperalgesia and allodynia in chronic constriction injury-induced neuropathic pain in rats. | Jaggi, AS. and Singh, N. 2013. Neurol Sci. 34: 297-304. PMID: 22382741
- Thrombin-induced NF-κB activation and IL-8/CXCL8 release is mediated by c-Src-dependent Shc, Raf-1, and ERK pathways in lung epithelial cells. | Lin, CH., et al. 2013. Cell Signal. 25: 1166-75. PMID: 23357535
- The Oxindole GW-5074 Inhibits JC Polyomavirus Infection and Spread by Antagonizing the MAPK-ERK Signaling Pathway. | Kaiserman, J., et al. 2023. mBio. e0358322. PMID: 36786589
Inhibitor of:
0610038D11Rik, 2610528A11Rik, 4930428D18Rik, A930016P21Rik, ACRV1, ACSVL4, AK5, ALP, AMIGO2, ANKRD10, ANKRD18B, ANKRD20A2, ANKRD20A4, ANKRD35, AP-2ε, ARL10, ARX, AS250, BBS2, BC011487, BTNL9, C10orf111, C14orf132, C15orf58, C1orf105, C1orf54, C9orf173, C9orf38, cadherin-26, cadherin-28, CASD1, CBLL1, CCDC36, CCDC60_Ccdc60, Cdc35, Centrin-4, CMTM1, CNTNAP3, CTHRC1, D6Mm5e, D830030K20Rik, DCC, Dendritic Cell marker, DNAHC12, DRP2, DSC3, EBLN2, EG433632, EG626740, Enzyme, ER81, Esp23, Extensin, eyes absent, FAM13b, FAM149A, FAM47B, FAM71F2, FHL1, FIZ, FOXI2, FRG2C, Gα i-2, Gα q, Gab 3, GAGE2E, GALC, GBP2, GDAP2, Gm281, Gm996, GPR112, GPR128, GPR133, GPR135, GPR35, GRXCR2, GTPBP2, HEATR4, Hinderin, HPA2c, HSFX2, IAH1, IDE, IQCF1, KIAA0195, KIAA1107, KIAA1166, KMO, Krox-26, LACTBL1, LIN-45, LOC100041220, LOC100041259, LOC100041376, LOC644978, LOC728675, LOC729823, LOC730270, LPCAT1, LRRC57, LRRK1, LYPD1, LYPD2, LYPLAL1, LYSMD1, mGBP8, MGC42105, MGC57346, MrgB1, MrgB3, MTUS2, MUP21, MUP7, MUP8, MUP9, MXL-1, Myelin P2, Myeov, myomesin-1, Myozenin 3, NBL4, Nef, NEURL1B, Nogo-R, NOR-1, Noxp20, NRIF2, NT5DC4, Olfr1110, Olfr463, Olfr464, Olfr466, Olfr467, Olfr57, Olfr570, Olfr608, Olfr611, Olfr614, Olfr615, Olfr616, Olfr617, Olfr618, Olr1462, Olr443, PC-PLD2, PCDGF, PCM1, PDZK7, Pgr15l, PI 4-kinase II β, Pitx1, PP2A-Cα, Ppapdc1a, PRAME like-7, PTH/PTHrP-R, PTP 1β, Rab 24, Rab 33A, Rab 39A, Rab GTPase (RAB; RAS oncogene), Raf-1, raf-A, Ral BP-1, Ral GPS1, RAMP1, Rap 1B, Rap 2A, RASSF4, RGL2, Rhox9, RSP3, RSU1, RUNDC3B, RUSC1, SAMC, SAMD1, Ser/Thr Protein Kinase, Ski, Sox-12, SPATA24, SRRD, SSTR3, SSXB2, striatin, Syndecan-3, Tas2r125, TBC1D3F, TM4SF19, TM4SF5, TMEFF2, TMEM147, TMEM200C, TMEM28, Trav3d-3, TSA-1, TSSK 3, TSSK 5, TTBK1, TudorSN, TWISTNB, V1RC18, V1RD11, V1RD12, V1RD19, V1RH14, V1RI10, V1RJ2, Vmn1r118, Vmn2r11, Vmn2r120, Vmn2r52, VN1R4, WSCD1, ZC3H6, ZFP28, Zfp599, Zfp738, Zfp867, ZFPL1, ZFR, ZHX2, Zip67, ZNF239, ZNF266, ZNF28, ZNF283, ZNF37A, ZNF462, ZNF518, ZNF525, ZNF528, ZNF530, ZNF540, ZNF546, ZNF547, ZNF548, ZNF620, ZNF643, ZNF691, and ZNF75.Activator of:
C130079G13Rik, CD9, CNTF, CREM, Cypt12, D030016E14Rik, D030074E01Rik, Dengue Virus, Dicer, Eapa2, Ear5, EDG-7, EG229862, EG243866, EG382265, EG434881, EG546488, EG624918, Fbxw21, FGF-15, FRP-2, GIN1, GPCR2037, GPR22, GPR34, hDcp1b, MARCO, NAB2, OTTMUSG00000010438, OTTMUSG00000010441, OTTMUSG00000016780, OTTMUSG00000016781, OTTMUSG00000016783, OTTMUSG00000016784, OTTMUSG00000016785, OTTMUSG00000016788, PCLN-1, PDE6D, PMEPA1, Rab 5B, Rab 7L1, Rent1, S-100A10, S-100A16, Sslp-1, TMEM161B, TSSK 6, and ZNF585A.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GW 5074, 5 mg | sc-200639 | 5 mg | $106.00 | |||
GW 5074, 25 mg | sc-200639A | 25 mg | $417.00 |