Date published: 2026-10-17

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Z39Ig 抗体 (6H8): sc-53977

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说明书
  • Z39Ig 抗体 6H8 是小鼠单克隆 IgG1 κ,Z39Ig抗体, 在6篇文献中引用,规格为200 µg/ml
  • 针对Z39Ig-转染的HeLa细胞(源自human)
  • Z39Ig 抗体 (6H8) 推荐用于WB, IP, IF 和 FCM,检测human 来源的 Z39Ig
  • 抗Z39Ig抗体(6H8)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 目前,我们还没有完成Z39Ig 抗体 (6H8)的首选二抗检测试剂的鉴定。这项工作正在进行中。
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Z39Ig 抗体(6H8)是一种小鼠单克隆 IgG1 kappa 轻链抗体,可通过免疫印迹(WB)、免疫荧光(IF)和流式细胞术(FCM)检测人源 Z39Ig 蛋白。抗 Z39Ig 抗体 (6H8) 有非共轭型和多种共轭型,包括琼脂糖、辣根过氧化物酶 (HRP)、藻红蛋白 (PE)、异硫氰酸荧光素 (FITC) 和多种 Alexa Fluor® 共轭物。Z39Ig 是免疫球蛋白超家族细胞粘附分子 (CAM) 的成员,在介导细胞-细胞和细胞-基质的相互作用中起着至关重要的作用。这些相互作用对许多生物过程至关重要,包括细胞生长、分化、免疫反应以及癌症转移。Z39Ig 主要在人类胎儿组织、成人肺部和胎盘中表达,突显了它在发育过程和组织稳态中的重要性。Z39Ig 定位于人类 X 染色体的近中心区域,Z39Ig 的表达对于胚胎的正常形态发育和神经元突触粘附至关重要,而这对于学习和记忆至关重要。包括 Z39Ig 在内的 CAM 基因的失调或突变与多种癌症有关,影响肿瘤的生长和转移,因此 Z39Ig 成为癌症生物学研究和治疗干预的重要靶点。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Z39Ig 抗体 (6H8) 参考文献:

  1. 克隆位于人类 X 染色体上的具有免疫球蛋白样结构域的新型基因 Z39Ig。  |  Langnaese, K., et al. 2000. Biochim Biophys Acta. 1492: 522-5. PMID: 11004523
  2. Z39Ig 与活化的巨噬细胞基因共同表达。  |  Walker, MG. 2002. Biochim Biophys Acta. 1574: 387-90. PMID: 11997108
  3. 通过 cDNA 减法和芯片分析确定人类树突状细胞亚群中差异表达的基因。  |  Ahn, JH., et al. 2002. Blood. 100: 1742-54. PMID: 12176896
  4. 免疫球蛋白超家族成员 Z39Ig 蛋白特异性单克隆抗体的特征。  |  Kim, JK., et al. 2005. Immunol Lett. 99: 153-61. PMID: 16009265
  5. CRIg:巨噬细胞吞噬循环病原体所需的补体受体。  |  Helmy, KY., et al. 2006. Cell. 124: 915-27. PMID: 16530040
  6. Z39Ig 在巨噬细胞上表达,可介导关节炎和动脉粥样硬化的炎症反应。  |  Lee, MY., et al. 2006. J Leukoc Biol. 80: 922-8. PMID: 16882875
  7. 成为或不成为 B7.  |  Zang, X. and Allison, JP. 2006. J Clin Invest. 116: 2590-3. PMID: 17016555
  8. VSIG4 是一种 B7 家族相关蛋白,是 T 细胞活化的负调控因子。  |  Vogt, L., et al. 2006. J Clin Invest. 116: 2817-26. PMID: 17016562
  9. C3b 与 CRIg 复合物的结构使人们对补体激活的调控有了更深入的了解。  |  Wiesmann, C., et al. 2006. Nature. 444: 217-20. PMID: 17051150

订购信息

产品名称产品编号规格价格数量收藏夹

Z39Ig 抗体 (6H8)

sc-53977
200 µg/ml
$322.00

Z39Ig (6H8): m-IgG Fc BP-HRP 套装

sc-551777
200 µg Ab; 10 µg BP
$361.00

Z39Ig 抗体 (6H8) AC

sc-53977 AC
500 µg/ml, 25% agarose
$424.00

Z39Ig 抗体 (6H8) HRP

sc-53977 HRP
200 µg/ml
$322.00

Z39Ig 抗体 (6H8) FITC

sc-53977 FITC
200 µg/ml
$336.00

Z39Ig 抗体 (6H8) PE

sc-53977 PE
200 µg/ml
$349.00

Z39Ig 抗体 (6H8) Alexa Fluor® 488

sc-53977 AF488
200 µg/ml
$364.00

Z39Ig 抗体 (6H8) Alexa Fluor® 546

sc-53977 AF546
200 µg/ml
$364.00

Z39Ig 抗体 (6H8) Alexa Fluor® 594

sc-53977 AF594
200 µg/ml
$364.00

Z39Ig 抗体 (6H8) Alexa Fluor® 647

sc-53977 AF647
200 µg/ml
$364.00

Z39Ig 抗体 (6H8) Alexa Fluor® 680

sc-53977 AF680
200 µg/ml
$364.00

Z39Ig 抗体 (6H8) Alexa Fluor® 790

sc-53977 AF790
200 µg/ml
$364.00

Is this Antibody Cross reactive to mouse crig/Z39Ig?

Asked by: finlaycm
Thank you for your question. We have not yet tested this antibody, Z39Ig (6H8): sc-53977, in mouse samples so we do not recommend the antibody for detection of this species.
Answered by: Technical Support
Date published: 2017-12-19

Can Z39Ig (6H8): sc-53977 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?

Asked by: TinTin
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent, Z39Ig (6H8): sc-53977 is available in a variety of direct conjugations, such as HRP, PE, FITC and AlexaFluors.
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by SCBT QC Lab from Great for multiple applicationsAntibody has been used to detect Z39Ig in human neutrophils by Flow Cytometry, Confocal Microscopy, Bactericidal Assay, and Neutrophil Extracellular Traps Assay in published research. -SCBT QC
Date published: 2023-09-14
Rated 5 out of 5 by Khalida from Excellent antibodyWe tested this antibody in cell culture experiment.it worked beautifully.
Date published: 2017-12-12
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Z39Ig 抗体 (6H8) is rated 4.7 out of 5 by 3.
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