Wnt-3a Antibody (YY-7): sc-80457
- Wnt-3a Antibody (YY-7) is a rat monoclonal IgG2a, cited in 6 publications, provided at 100 µg/ml
- raised against full length recombinant Wnt-3a of mouse origin
- recommended for detection of Wnt-3a of mouse origin by WB, IP and ELISA; non cross-reactive with Wnt-1, Wnt-4 or Wnt-5a
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Wnt-3a Antibody (YY-7). This work is in progress.
Wnt-3a Antibody (YY-7) is a rat monoclonal IgG2a antibody that detects Wnt-3a in mouse samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Wnt-3a plays a crucial role in intercellular signaling, particularly in mediating cytoskeletal reorganization and regulating the development of the hippocampus, which is essential for cognitive functions such as learning and memory. The importance of Wnt-3a′s function is underscored by involvement in oncogenesis and developmental processes, as Wnt-3a influences cell fate and patterning during embryogenesis. Notably, Wnt-3a is highly conserved across species, with human Wnt-3a exhibiting 96% homology to mouse Wnt-3a and 84% homology to human Wnt-3, indicating a fundamental role in biological systems. The human Wnt-3a gene is located at chromosome 1q42, where Wnt-3a clusters with the Wnt-14 gene, further emphasizing significance in the Wnt signaling pathway. Anti-Wnt-3a antibody (YY-7) is an invaluable tool for researchers studying the intricate mechanisms of cell signaling and development in mouse models.
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Wnt-3a Antibody (YY-7) References:
- Inhibition by Wnt-1 or Wnt-3a of nerve growth factor-induced differentiation of PC12 cells is reversed by bisindolylmaleimide-I but not by several other PKC inhibitors. | Chou, AH. and Howard, BD. 2002. Oncogene. 21: 6348-55. PMID: 12214275
- Captopril attenuates TAC-induced heart failure via inhibiting Wnt3a/β-catenin and Jak2/Stat3 pathways. | Zhang, Y., et al. 2019. Biomed Pharmacother. 113: 108780. PMID: 30889487
- Role of Wnt3a in the pathogenesis of cancer, current status and prospective. | Pashirzad, M., et al. 2019. Mol Biol Rep. 46: 5609-5616. PMID: 31236761
- Therapeutic Potential of Wnt-3a in Neurological Recovery after Spinal Cord Injury. | Gao, K., et al. 2019. Eur Neurol. 81: 197-204. PMID: 31336380
- Wnt-3a Induces Cytokine Release in Human Mast Cells. | Tebroke, J., et al. 2019. Cells. 8: PMID: 31683769
- Wnt family member 4 (WNT4) and WNT3A activate cell-autonomous Wnt signaling independent of porcupine O-acyltransferase or Wnt secretion. | Rao, DM., et al. 2019. J Biol Chem. 294: 19950-19966. PMID: 31740580
- WNT3A-loaded exosomes enable cartilage repair. | Thomas, BL., et al. 2021. J Extracell Vesicles. 10: e12088. PMID: 34025953
- Quantitative Profiling of WNT-3A Binding to All Human Frizzled Paralogues in HEK293 Cells by NanoBiT/BRET Assessments. | Kozielewicz, P., et al. 2021. ACS Pharmacol Transl Sci. 4: 1235-1245. PMID: 34151213
- Wnt3a is a promising target in colorectal cancer. | Tufail, M. and Wu, C. 2023. Med Oncol. 40: 86. PMID: 36719558
- Wnt3a-Loaded Extracellular Vesicles Promote Alveolar Epithelial Regeneration after Lung Injury. | Gao, L., et al. 2023. Adv Sci (Weinh). 10: e2206606. PMID: 37072558
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Wnt-3a Antibody (YY-7) | sc-80457 | 100 µg/ml | $322.00 |