Date published: 2025-9-6
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VLDLR Antibody (6A6) - Western Blotting - Image 362061
VLDLR 抗体 (6A6): sc-18824. A-10 (A) 和 NIH/3T3 (B) 全细胞裂解液中 VLDLR 表达的 Western 印迹分析.
VLDLR 抗体 (6A6): sc-18824. A-10 (A) 和 NIH/3T3 (B) 全细胞裂解液中 VLDLR 表达的 Western 印迹分析.

VLDLR 抗体 (6A6): sc-18824

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说明书
  • VLDLR抗体(6A6)是小鼠单克隆IgG1 λ VLDLR抗体, 在50篇文献中引用，规格为200 µg/ml
  • 针对C-terminus 10个氨基酸肽的rat来源，与VLDL受体相对应
  • VLDLR 抗体 (6A6) 推荐用于 WB, IP, IF 和 IHC(P)，检测mouse, rat 和human 来源的 VLDLR
  • 抗VLDLR抗体（6A6）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取VLDLR (6A6): sc-18824的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgGλ BP-HRP (mouse IgGλ binding protein-HRP)是 VLDLR 抗体 (6A6) 在 WB and IHC(P) 应用中的首选二抗检测试剂。该试剂现与VLDLR 抗体 (6A6) 组合成套装提供。 (请参阅下面的订购信息)。其他m-IgGλ BP 偶联产品，请参阅我们的 小鼠 IgG 结合蛋白完整列表。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

VLDLR抗体（6A6）是一种小鼠单克隆IgG1抗体，可通过蛋白质印迹（WB）、免疫沉淀（IP）、免疫荧光（IF）和免疫组织化学检测小鼠、大鼠和人类来源的VLDLR蛋白。VLDLR 单克隆抗体（6A6）有非结合型和多种结合型，包括琼脂糖、辣根过氧化物酶（HRP）、藻红蛋白（PE）、异硫氰酸荧光素（FITC）和多种 Alexa Fluor® 结合物。VLDLR蛋白（即极低密度脂蛋白受体）是LDL受体基因家族的重要成员，在脂质代谢和神经元发育中发挥着重要作用。VLDLR主要位于大脑、心脏、骨骼肌和脂肪组织中，参与调节细胞外Reelin和细胞质mDab1（哺乳动物失活蛋白）之间的相互作用。这种相互作用对于激活酪氨酸激酶通路至关重要，该通路可调节神经元在脑发育过程中沿放射状胶质纤维网络的迁移，凸显了VLDLR在神经发育过程和脂质稳态中的重要性。此外，VLDLR在折叠过程中与受体相关蛋白（RAP）结合，这对VLDLR细胞外区域的正常分泌至关重要，进一步强调了VLDLR在细胞过程中的功能意义。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

VLDLR 抗体 (6A6) 参考文献:

  1. 在缺乏 VLDL 受体和 ApoE 受体 2 的基因敲除小鼠中，Reeler/Disabled 类神经元迁移中断。  |  Trommsdorff, M., et al. 1999. Cell. 97: 689-701. PMID: 10380922
  2. 39 kDa 受体相关蛋白（RAP）促进极低密度脂蛋白受体胞外区域的分泌和配体结合：与低密度脂蛋白受体不同途径的含义。  |  Sato, A., et al. 1999. Biochem J. 341 (Pt 2): 377-83. PMID: 10393096
  3. 受体相关蛋白的羧基末端结构域通过与受体的三个氨基末端配体结合重复序列相互作用，促进极低密度脂蛋白受体的正常折叠和运输。  |  Savonen, R., et al. 1999. J Biol Chem. 274: 25877-82. PMID: 10464330
  4. 小鼠极低密度脂蛋白受体（VLDLR）：基因结构, 组织特异性表达以及饮食和发育调控。  |  Tiebel, O., et al. 1999. Atherosclerosis. 145: 239-51. PMID: 10488949
  5. 极低密度脂蛋白受体的功能域：配体结合和酸依赖性配体解离机制的分子分析。  |  Mikhailenko, I., et al. 1999. J Cell Sci. 112 (Pt 19): 3269-81. PMID: 10504332
  6. Reelin 是脂蛋白受体的配体。  |  D'Arcangelo, G., et al. 1999. Neuron. 24: 471-9. PMID: 10571240
  7. Reelin 与 VLDL 受体和 ApoE 受体 2 的直接结合可诱导 disabled-1 的酪氨酸磷酸化并调节 tau 的磷酸化。  |  Hiesberger, T., et al. 1999. Neuron. 24: 481-9. PMID: 10571241
  8. 极低密度脂蛋白受体以RasGRF1/CaMKII依赖的方式调节树突棘的形成。  |  DiBattista, AM., et al. 2015. Biochim Biophys Acta. 1853: 904-17. PMID: 25644714
  9. 脓毒症期间，极低密度脂蛋白受体将脂多糖隔离在脂肪组织中。  |  Shimada, T., et al. 2020. Crit Care Med. 48: 41-48. PMID: 31651422
  10. 可溶性极低密度脂蛋白受体（sVLDLR）抑制新生血管性老年黄斑变性的纤维化。  |  Ma, X., et al. 2021. FASEB J. 35: e22058. PMID: 34820908
  11. 胰腺星状细胞中极低密度脂蛋白受体增强的脂质代谢促进了胰腺纤维化。  |  Yang, X., et al. 2022. Immunity. 55: 1185-1199.e8. PMID: 35738281
  12. 血栓素原1和Reelin通过Vldlr调节心脏生长和修复。  |  Pei, L., et al. 2024. Basic Res Cardiol. 119: 169-192. PMID: 38147128

订购信息

产品名称产品编号规格价格数量收藏夹

VLDLR 抗体 (6A6)

sc-18824
200 µg/ml
$316.00

VLDLR (6A6): m-IgGλ BP-HRP 套装

sc-520686
200 µg Ab, 40 µg BP
$354.00

VLDLR 抗体 (6A6) AC

sc-18824 AC
500 µg/ml, 25% agarose
$416.00

VLDLR 抗体 (6A6) HRP

sc-18824 HRP
200 µg/ml
$316.00

VLDLR 抗体 (6A6) FITC

sc-18824 FITC
200 µg/ml
$330.00

VLDLR 抗体 (6A6) PE

sc-18824 PE
200 µg/ml
$343.00

VLDLR 抗体 (6A6) Alexa Fluor® 488

sc-18824 AF488
200 µg/ml
$357.00

VLDLR 抗体 (6A6) Alexa Fluor® 546

sc-18824 AF546
200 µg/ml
$357.00

VLDLR 抗体 (6A6) Alexa Fluor® 594

sc-18824 AF594
200 µg/ml
$357.00

VLDLR 抗体 (6A6) Alexa Fluor® 647

sc-18824 AF647
200 µg/ml
$357.00

VLDLR 抗体 (6A6) Alexa Fluor® 680

sc-18824 AF680
200 µg/ml
$357.00

VLDLR 抗体 (6A6) Alexa Fluor® 790

sc-18824 AF790
200 µg/ml
$357.00

Is there a mouse isotype control (PE conjugate) that I can use for the VLDLR Antibody (6A6) PE (sc-18824 PE) for flow cytometry

Asked by: DiriD
Thank you for your question . We recommend using a IgG1 isotype control. https://www.scbt.com/browse/Control-IgGs-and-IgG-Conjugates/_/N-1j3ajah?Nr=AND%28OR%28product.catalogId%3AscbtCatalog%29%2Cproduct.discontinuedFlag%3A0%2Cproduct.siteId%3AscbtSite%2Cproduct.webDisplayFlag%3A1%2Cproduct.suppressDisplayFlag%3A0%29&autoSuggest=true&dataType=json
Answered by: BlakeJ
Date published: 2023-01-12

can I get some antibodies for trial before buying it?

Asked by: wei ji
Thank you for your question. Please contact our Technical Service Department for more information on how to receive a free 10 ug sample of this monoclonal antibody.
Answered by: Technical Service
Date published: 2022-04-29

What is the recommended dilution for the VLDLR Antibody (6A6) FITC in flow cytometry?

Asked by: Ray C
Thank you for your question. We recommend using 1 µg of fluorochrome-conjugated antibodies to 100 µl of the prepared cell suspension (equal to 1 million cells) to each tube. A link to our general recommended protocol for flow cytometry is below. https://www.scbt.com/resources/protocols/flow-cytometry
Answered by: Technical Support
Date published: 2020-07-06

I need to use an antibody to detect the protein in samples of avian origin. Do you know if this mouse monoclonal antibody will work?

Asked by: jerojero
Please contact our Technical Service Department and we would be happy to perform sequence analysis and review our data to answer any questions you may have about additional species reactivity.
Answered by: Technical Support 15
Date published: 2017-01-11

What is the recommended secondary reagent to be used with this mouse monoclonal primary?

Asked by: jerojero
We recommend using one our exclusive Mouse IgG Binding Proteins as a secondary detection reagent. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety
Answered by: Technical Support 15
Date published: 2017-01-11
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Rated 4 out of 5 by from 抗体做western还可以申请的试用装，用鼠脑组织蛋白检测，可以看到目的条带，只是用BSA封闭后有较多杂带，不知道奶粉封闭会不会好很多。
Date published: 2018-01-04
Rated 4 out of 5 by from 离体少突胶质祖细胞染色免费申请的小样进行染色，离体少突胶质祖细胞1:40染出，但是大鼠组织冰冻切片15um 1:50未能染出结果，可能浓度低。
Date published: 2017-12-04
Rated 4 out of 5 by from Review for VLDLRI applied for this antibody one month ago and I used it.The quality of this antibody ought to no problem,but it can`t be used chicken this genus of follicular tissue.I am sorry for that.Thank you for your corporation`s antibody.
Date published: 2017-10-09
Rated 5 out of 5 by from Excellent, versatile antibodyThe VLDLR Antibody (6A6): sc-18824 works very well for multiple applications including WB, IP, IF and IHC(P). This antibody has been cited over 10 times for further verification.
Date published: 2017-01-12
Rated 4 out of 5 by from Worked well with transfected lysate by WBWorked well with transfected lysate by WB. -SCBT QC
Date published: 2015-06-03
Rated 4 out of 5 by from Publishable data in IHC using mouse brainPublishable data in IHC using mouse brain. -SCBT Publication Review
Date published: 2015-05-16
Rated 5 out of 5 by from Produced great immunoperoxidase cytoplasmicProduced great immunoperoxidase cytoplasmic staining in formalin fixed, paraffin-embedded human pancreas tissue. -SCBT QC
Date published: 2015-05-10
Rated 4 out of 5 by from Publishable data in WB using rat NeonatalPublishable data in WB using rat Neonatal cardiomyocytes -SCBT Publication Review
Date published: 2015-05-06
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VLDLR 抗体 (6A6) is rated 4.2 out of 5 by 9.
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