Vitronectin 75 Antibody (GMA-900): sc-65972
- Vitronectin 75 Antibody (GMA-900) is a mouse monoclonal IgG2a provided at 100 µg/ml
- raised against Vitronectin 75 of human origin
- recommended for detection of Vitronectin 75 of human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Vitronectin 75 Antibody (GMA-900). This work is in progress.
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Vitronectin 75 Antibody (GMA-900) is a mouse monoclonal IgG2a light chain antibody that detects Vitronectin in human samples through applications such as western blotting (WB) and immunoprecipitation (IP). Vitronectin is a crucial extracellular matrix glycoprotein that plays a significant role in various biological processes, including cell adhesion, migration, and wound healing. Anti-Vitronectin antibody (GMA-900) recognizes a unique structure featuring an RGD (Arg-Gly-Asp) sequence, which is vital for binding to integrins and facilitating cell attachment. This interaction is essential for maintaining tissue integrity and promoting cellular responses during injury repair. Notably, increased levels of Vitronectin have been observed in migrating cells, highlighting its importance in the wound healing process. Additionally, Vitronectin interacts with several proteins, including plasminogen activators and plasminogen activator inhibitor-1 (PAI-1), which can modulate its function and influence cell migration dynamics. The ability of Vitronectin to enhance smooth muscle cell migration while being regulated by PAI-1 underscores its critical role in tissue remodeling and repair mechanisms. Vitronectin monoclonal antibody (GMA-900) serves as an invaluable tool for researchers studying the extracellular matrix and its impact on cellular behavior.
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LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Vitronectin 75 Antibody (GMA-900) References:
- Vitronectin receptors in vascular disorders. | Mousa, SA. 2002. Curr Opin Investig Drugs. 3: 1191-5. PMID: 12211413
- alphav Vitronectin receptors in vascular-mediated disorders. | Mousa, SA. 2003. Med Res Rev. 23: 190-9. PMID: 12500288
- Vitronectin in atherosclerotic disease. | Ekmekçi, OB. and Ekmekçi, H. 2006. Clin Chim Acta. 368: 77-83. PMID: 16460719
- Functional role of vitronectin in breast cancer. | Bera, A., et al. 2020. PLoS One. 15: e0242141. PMID: 33211735
- Vitronectin-Derived Peptide Promotes Reparative Dentin Formation. | Park, C., et al. 2022. J Dent Res. 101: 1481-1489. PMID: 35708468
- Role of Vitronectin and Its Receptors in Neuronal Function and Neurodegenerative Diseases. | Ruzha, Y., et al. 2022. Int J Mol Sci. 23: PMID: 36293243
- Vitronectin-based hydrogels recapitulate neuroblastoma growth conditions. | Monferrer, E., et al. 2022. Front Cell Dev Biol. 10: 988699. PMID: 36425532
- Vitronectin promotes immunothrombotic dysregulation in the venular microvasculature. | Uhl, B., et al. 2023. Front Immunol. 14: 1078005. PMID: 36845099
- Macrophage promotes fibroblast activation and kidney fibrosis by assembling a vitronectin-enriched microenvironment. | Peng, Y., et al. 2023. Theranostics. 13: 3897-3913. PMID: 37441594
- Identification of SPP1+ macrophages in promoting cancer stemness via vitronectin and CCL15 signals crosstalk in liver cancer. | Wang, Y., et al. 2024. Cancer Lett. 604: 217199. PMID: 39216547
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Vitronectin 75 Antibody (GMA-900) | sc-65972 | 100 µg/ml | $322.00 |