Date published: 2025-9-7

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Unc18-2 抗体 (B-2): sc-376639

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说明书
  • Unc18-2抗体(B-2)是小鼠单克隆IgM (kappa轻链),规格为200 µg/ml
  • 特异性抗原位于human物种的Unc18-2的内部区域内的氨基酸481-519之间
  • 推荐用于 mouse, rat 和 human 来源的Unc18-2 WB, IP, IF 和 ELISA检测
  • 关于如何获取Unc18-2 (B-2): sc-376639免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • 目前,我们还没有完成Unc18-2 抗体 (B-2)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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    関連項目

    Unc18-2抗体(B-2)是一种IgM κ小鼠单克隆Unc18-2抗体,可通过WB、IP、IF和ELISA检测小鼠、大鼠和人类来源的Unc18-2。Unc18-2抗体(B-2)以非偶联的抗Unc18-2抗体形式提供。Unc18-1、-2和-3(syntaxin结合蛋白1-3,STXBP1-3,UNC18-a-c,MUNC18-1-3)是伴侣分子,它们阻止syntaxin与同源SNARE(可溶性NSF附着蛋白(SNAP)受体)蛋白的相互作用并调节胞吐作用。Unc18-1-3 mRNA存在于RBL-2H3肥大细胞、小鼠骨髓源性肥大细胞(BMMC)和血小板中。Unc18-1的Ser 313是蛋白激酶C的磷酸化位点,而Thr 574是细胞周期蛋白依赖性激酶5的磷酸化位点,调节Unc18-1/syntaxin1A的相互作用。在肾上腺嗜铬细胞中,Unc18-1的Ser 313在响应佛波酯治疗时被磷酸化。Unc18-2与肠道、近端小管和集合管上皮细胞顶端质膜上的Syntaxin 3共定位。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    Unc18-2 抗体 (B-2) 参考文献:

    1. 蛋白激酶 C 对 Munc18 的磷酸化可调节外吞动力学。  |  Barclay, JW., et al. 2003. J Biol Chem. 278: 10538-45. PMID: 12519779
    2. Sec1/Munc18 蛋白在血小板外吞过程中的作用  |  Schraw, TD., et al. 2003. Biochem J. 374: 207-17. PMID: 12773094
    3. 醇慢性胰腺炎涉及 Munc18c 从胰腺针叶基底膜表面移位。  |  Gaisano, HY., et al. 2004. Pancreas. 28: 395-400. PMID: 15097857
    4. 外吞过程中囊泡融合和释放晚期事件中的 Syntaxin/Munc18 相互作用  |  Graham, ME., et al. 2004. J Biol Chem. 279: 32751-60. PMID: 15175344
    5. 在 HEK293 细胞中调控 SNARE 配对的 syntaxin1A-munc18 复合物。  |  Gladycheva, SE., et al. 2004. J Physiol. 558: 857-71. PMID: 15218059
    6. 荧光共振能量转移报告了体内 syntaxin1a 与 Munc18-1 相互作用的特性。  |  Liu, J., et al. 2004. J Biol Chem. 279: 55924-36. PMID: 15489225
    7. Munc18-1 通过不依赖于合成蛋白的蛋白质相互作用调控外渗的早期和晚期阶段。  |  Ciufo, LF., et al. 2005. Mol Biol Cell. 16: 470-82. PMID: 15563604
    8. 蛋白酶活化受体-1激活内皮细胞可诱导蛋白激酶Calpha依赖性磷酸化合成蛋白4和Munc18c:在p-选择素表达信号中的作用。  |  Fu, J., et al. 2005. J Biol Chem. 280: 3178-84. PMID: 15576373
    9. 肥大细胞中 Munc18 同工酶的表达和转录调控。  |  Nigam, R., et al. 2005. Biochim Biophys Acta. 1728: 77-83. PMID: 15777698

    订购信息

    产品名称产品编号规格价格数量收藏夹

    Unc18-2 抗体 (B-2)

    sc-376639
    200 µg/ml
    $316.00

    Unc18-2 (B-2) 中和勝肽

    sc-376639 P
    100 µg/0.5 ml
    $68.00

    What application is the blocking peptide sc-376639 P appropriate for?

    Asked by: Professor Griffin
    Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
    Answered by: Technical Support
    Date published: 2017-02-27
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    Rated 1 out of 5 by from No IF signals in mice/rat mandible ameloblastsThis antibody doesn't show bindings on PFA fixed and paraffin embedded sections from mice/rat mandible ameloblasts.
    Date published: 2017-07-06
    Rated 5 out of 5 by from Great immunofluorescence cytoplasmic andGreat immunofluorescence cytoplasmic and membrane staining in methanol-fixed HeLa cells. -SCBT QC
    Date published: 2015-04-29
    Rated 5 out of 5 by from Good specificity in WB in human transfected 293TGood specificity in WB in human transfected 293T, Jurkat and K-562 whole cell lysates. -SCBT QC
    Date published: 2015-03-02
    Rated 5 out of 5 by from Strong band in WB in human transfected 293TStrong band in WB in human transfected 293T whole cell lysates. -SCBT QC
    Date published: 2015-01-26
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    Unc18-2 抗体 (B-2) is rated 4.0 out of 5 by 4.
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