Date published: 2026-7-22
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ULBP1 Antibody (3F1) - Immunofluorescence - Image 142906
ULBP1 抗体 (3F1): sc-53131. 免疫荧光染色甲醇固定的 HeLa 细胞, 显示细胞质定位.
ULBP1 Antibody (3F1) - Immunofluorescence - Image 142906
ULBP1 抗体 (3F1): sc-53131. 免疫荧光染色甲醇固定的 HeLa 细胞, 显示细胞质定位.
ULBP1 Antibody (3F1) - Flow Cytometry - Image 38326
ULBP1 抗体 (3F1): sc-53131. 用 ULBP1 抗体 (3F1) 染色的 C1R 模拟 (黑线直方图) 和 C1R-ULBP1 转染物 (实线直方图) 的间接 FCM 分析, 然后用 PE 结合物山羊抗小鼠 IgM 染色. 由弗雷德-哈钦森癌症研究中心的 Nobuyoshi Hanaoka 和 Veronika Groh 慷慨提供.
ULBP1 抗体 (3F1): sc-53131. 免疫荧光染色甲醇固定的 HeLa 细胞, 显示细胞质定位.

ULBP1 抗体 (3F1): sc-53131

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说明书
  • ULBP1 抗体 3F1 是小鼠单克隆 IgM κ，ULBP1抗体, 在6篇文献中引用，规格为200 µg/ml
  • 针对纯化的human ULBP1
  • 推荐用于 human 来源的ULBP1 IP, IF 和 FCM检测
  • 还提供无叠氮化物阻断剂，sc-53131 L，200 µg/0.1 ml
  • m-IgGκ BP-HRP是ULBP1 Antibody (3F1). 的首选辅助检测试剂。该试剂现可与ULBP1 Antibody (3F1) 搭配使用（请参阅下面的订购信息）。有关其它 m-IgGκ BP 结合物，请参阅我们完整的小鼠 IgG 结合蛋白列表。
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関連項目

额外ULBP/RAET1抗体，包括Rae-1 δ, ULBP1, ULBP2, ULBP3, ULBP4和ULBP5

ULBP1 Antibody (3F1)是一种IgM κ型小鼠单克隆ULBP1抗体(也称为ULBP1抗体)，通过IP、IF和FCM检测人源性ULBP1蛋白。ULBP1抗体(3F1)是一种非偶联的抗ULBP1抗体。免疫系统包含遗传编码的子系统，它们监测细胞外环境，以清除病原体和溶解异常或转化的组织。巨细胞病毒UL16结合蛋白(称为ULBPs)是gpi连接的糖蛋白，属于扩展的MHCⅰ类家族，与MHCⅰ类多肽相关序列B(称为MICB)有远缘关系。ULBP和MICB蛋白是激活性受体NKG2D/DAP10的配体，NKG2D/DAP10引起淋巴细胞活化，从而分泌细胞因子，如干扰素γ和肿瘤细胞溶解。ULBP或MICB与NKG2D/DAP10的相互作用可被可溶性形式的UL16阻断。ulbp刺激NK细胞、CD8 α / β T细胞和γ / δ T细胞产生细胞因子和趋化因子。可溶性形式的ULBPs诱导蛋白酪氨酸磷酸化和Janus激酶2、STAT5、细胞外信号调节激酶、丝裂原活化蛋白激酶和磷脂酰肌醇3-激酶(PI 3-激酶)/Akt信号转导通路的激活。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

ULBP1 抗体 (3F1) 参考文献:

  1. 新型 MHC I 类相关分子 ULBPs 与 CMV 糖蛋白 UL16 结合，并通过 NKG2D 受体刺激 NK 细胞毒性。  |  Cosman, D., et al. 2001. Immunity. 14: 123-33. PMID: 11239445
  2. ULBP1, 2, 3：与人类巨细胞病毒糖蛋白 UL16 结合并激活 NK 细胞的新型 MHC I 类相关分子。  |  Kubin, M., et al. 2001. Eur J Immunol. 31: 1428-37. PMID: 11465099
  3. UL16 结合蛋白是一种新型 MHC I 类相关蛋白，它与 NKG2D 结合并激活原代 NK 细胞中的多种信号通路。  |  Sutherland, CL., et al. 2002. J Immunol. 168: 671-9. PMID: 11777960
  4. 人类巨细胞病毒感染对激活 NK 细胞 NKG2D 受体配体的影响：病毒 UL16 蛋白抵消了 UL16 结合蛋白 (ULBP)1 和 ULBP2 的上调。  |  Rölle, A., et al. 2003. J Immunol. 171: 902-8. PMID: 12847260
  5. 通过 NKG2D 刺激人类 NK 细胞和 T 细胞的应激诱导蛋白 ULBP 和 MICA 的细胞表面组织。  |  Eleme, K., et al. 2004. J Exp Med. 199: 1005-10. PMID: 15051759
  6. UL16 结合蛋白  |  Cao, W. and He, W. 2004. Immunobiology. 209: 283-90. PMID: 15518340
  7. 自然杀伤细胞对缺失应激诱导型 ULBP 的 PIGA 突变细胞进行免疫选择。  |  Hanaoka, N., et al. 2006. Blood. 107: 1184-91. PMID: 16195329
  8. 树突状细胞上 NKG2D 配体 UL16 结合蛋白-1（ULBP-1）的表达。  |  Schrama, D., et al. 2006. Eur J Immunol. 36: 65-72. PMID: 16342232

订购信息

产品名称产品编号规格价格数量收藏夹

ULBP1 抗体 (3F1)

sc-53131
200 µg/ml
$322.00

ULBP1 (3F1): m-IgGκ BP-HRP 套装

sc-552773
200 µg Ab; 40 µg BP
$361.00

ULBP1 抗体 (3F1) L

sc-53131 L
200 µg/0.1 ml
$322.00

Which secondaries are good for immunofluorescence? Do I need IgM secondaries?

Asked by: Kale
Thank you for your question. This mouse monoclonal antibody, ULBP1 (3F1): sc-53131, is an IgM and using an isotype-specific secondary antibody (anti-mouse IgM) is recommended. Alternatively, we also recommend using our mouse IgG kappa binding protein (m-IgGκ BP) conjugated to a fluorochrome, such as fluorescein (FITC), m-IgGκ BP-FITC: sc-516140. Other fluorochromes available include: m-IgGκ BP-CFL 488: sc-516176, m-IgGκ BP-CFL 555: sc-516177, or m-IgGκ BP-CFL 594: sc-516178. We have tested and confirmed reactivity of our mouse IgG kappa binding protein with mouse IgM.
Answered by: Technical Support
Date published: 2017-11-22

I bought the L form of this antibody, sc-53131 L for blocking (neutralization). How long can I store this at in the refridgerator?

Asked by: Trav11
The L form of the antibody should be stored at -20°C. Once thawed, we recommend using as soon as possible, although it is usually stable for up to 2 weeks at 4 degrees.
Answered by: Technical Support
Date published: 2017-02-24
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Rated 2 out of 5 by from Very faint signal by FCMThis antibody was tested by indirect FCM on HFF cells but does not give a very clean signal, even at dilution 1:50.
Date published: 2018-11-02
Rated 4 out of 5 by from Very good antibodyI got the sample from santa cruz last month. This work perfectly in the lung fibroblasts that we work with. I am really glad that it worked as I did not find any other better antibody. Good luck...
Date published: 2018-01-17
Rated 5 out of 5 by from Good Fluorescent StainingThis ULBP1 antibody shows good cytoplasmic staining when used with methanol-fixed HeLa cells in IF. Also works in Flow Cytometry.
Date published: 2017-02-02
Rated 4 out of 5 by from IHC(P) publishable data with human HCC tissuesIHC(P) publishable data with human HCC tissues - SCBT Publication Review
Date published: 2015-05-02
Rated 4 out of 5 by from Clear immunofluorescence cytoplasmic stainingClear immunofluorescence cytoplasmic staining in methanol-fixed HeLa cells. -SCBT QC
Date published: 2015-02-08
Rated 4 out of 5 by from Good indirect FCM data of C1R mock and C1RGood indirect FCM data of C1R mock and C1R-ULBP1 transfectants stained with ULBP1 -SCBT QC
Date published: 2014-09-29
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ULBP1 抗体 (3F1) is rated 3.8 out of 5 by 6.
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