UCN-01 CAS: 112953-11-4
MF: C28H26N4O4
MW: 482.53
A selective inhibitor of protein kinase C.

UCN-01 (CAS 112953-11-4)

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备用名: 7-hydroxystaurosporine
应用; UCN-01 is a selective inhibitor of protein kinase C
CAS号码: 112953-11-4
纯度: >95%
分子量: 482.53
分子式: C28H26N4O4
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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UCN-01 is a Staurosporine (sc-3510) analogue that acts as a selective inhibitor of protein kinase C and is reported to potently inhibit MK2. The compound has been shown to induce UCN-01 G1 phase accumulation, dephosphorylate Rb and CDK2 proteins, and induce CDK inhibitor p21/Cip1/WAF1/Sdi1 in A431 (sc-2201) cells with mutated p53. Additionally, UCN-01 has been demonstrated to suppress protein expression of thymidylate synthase and E2F-1, inhibit DNA damage checkpoint kinase hChk1, and interrupt the PDK1-Akt survival signaling pathway. UCN-01 has also been noted to inhibit cell proliferation in HNSCC cells.


参考文献

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9. Sato, S., et al. 2002. Oncogene. 21: 1727-1738. PMID: 11896604
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物理状态 :
Solid
溶解度 :
Soluble in DMSO or EtOH.
保存 :
Store at 4° C
熔点 :
314.42° C (Predicted)
沸点 :
717.98° C (Predicted)
密度 :
1.6 g/cm3 (Predicted)
仅供科研使用。不可用于诊断或治疗。
PubChem CID :
SMILES :
C[[email protected]@]12[[email protected]@H]([[email protected]@H](C[[email protected]@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)[[email protected]](NC6=O)O)NC)OC

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PMID: # 25633853  Dong, J.|Wang, Z.|Zou, P.|Zhang, G.|Dong, X.|Ling, X.|Zhang, X.|Liu, J.|Ye, D.|Cao, J.|Ao, L.| et al. 2015. Chem Res Toxicol. 28: 518-31.

PMID: # 17540843  Pei, XY. et al. 2007. Blood. 110: 2092-2101.

PMID: # 15767555  Hahn, M. et al. 2005. Mol. Cancer Ther. 4: 457-470.

PMID: # 15548112  Mack, PC. et al. 2004. Radiat. Res. 162: 623-634.

PMID: # 12488556  Wang, S. et al. 2003. Mol. Pharmacol. 63: 232-242.

PMID: # 12399544  Zhao, H. et al. 2002. Proc. Natl. Acad. Sci. USA. 99(23): 14795-800.

PMID: # 12384435  Dai, Y. et al. 2002. Blood. 100: 3333-3343.

PMID: # 10577141  Chen, X. et al. 1999. Oncogene. 18: 5691-5702.

PMID: # 9837924  Yu, L. et al. 1998. J. Biol. Chem. 273: 33455-33464.

PMID: # 29511342  Cell Death Differ. 1967-1979.

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