UBE2H Antibody (E-3): sc-515702

UBE2H Antibody (E-3) is a mouse monoclonal IgG2b antibody that detects UBE2H in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). UBE2H, also known as UBC8, UBCH, UBCH2, or E2-20K, is a 183 amino acid protein that plays a crucial role in the ubiquitin-proteasome system, which maintains cellular homeostasis by regulating protein degradation. This process controls the levels of various proteins, including those involved in cell cycle regulation and stress responses, preventing the accumulation of damaged or misfolded proteins that could lead to cellular dysfunction or disease. UBE2H functions as an E2 ubiquitin-conjugating enzyme, facilitating the transfer of ubiquitin moieties to target proteins, such as Histone H2A, which regulates gene expression and DNA repair. The conservation of UBE2H across species, with 100% identity to mouse counterpart and 98% identity to homologs in frogs and zebrafish, underscores its fundamental role in cellular processes. Additionally, the existence of multiple isoforms of UBE2H due to alternative splicing highlights the complexity of its regulation and function, making anti-UBE2H antibody (E-3) an invaluable tool for researchers studying ubiquitination and its implications in various biological contexts.

The preferred UBE2H antibody is UBE2H Antibody (G-2): sc-515567.