U-83836E CAS: 122003-11-6
MF: C30H44N6O2•2HCl
MW: 593.6
An agent that prevents hydrogen peroxide-induced F2 isoprostane production.

U-83836E (CAS 122003-11-6)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 138ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
同义词: (-)2-((4-(2,6-di-1-Pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl)methyl)-3,4-dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran-6-ol dihydrochloride
应用; An agent that prevents hydrogen peroxide-induced F2 isoprostane production
CAS号码: 122003-11-6
纯度: 98%
分子量: 593.6
分子式: C30H44N6O22HCl
* 参考分析证明 大量特定数据 (包括水 含量).
提交对此产品的评价,获得15个CruzCredits

U-83836E prevents hydrogen peroxide-induced F2 isoprostane production in renal proximal tubular cells, prevents free radical mediated effects of oxyhemoglobin in vascular smooth muscle, and reduces secondary brain injury in a rabbit model of cryogenic trauma. Research shows that U-83836E improves survival of rat embryonic mesencephalic tissue stored at 4° C, and mitigates the toxicity of methanol on the antioxidant system of the rat brain. Western blot of cardiac tissue pretreated with U-83836E shows increase expression of HSP 70 (HSP72).


参考文献

1. Vollrath, B., et al. 1995. Cardiovasc. Res. 30: 619-626. PMID: 8575010
2. Wilson, J.T., et al. 1995. J Trauma. 39: 473-477. PMID: 7473911
3. Salahudeen, A., et al. 1995. J. Am. Soc. Nephrol. 6: 1300-1303. PMID: 8589301
4. Grasbon-Frodl, E.M., et al. 1996. Brain Res. Bull. 39: 341-347. PMID: 9138743
5. Farbiszewski, R., et al. 2000. Toxicology. 156: 47-55. PMID: 11162875
6. Labruto, F., et al. 2006. Acad Emerg Med. 13: 7-12. PMID: 16365323
7. Sayyed, S.G., et al. 2006. Life Sci. 79: 777-783. PMID: 16581090

物理状态 :
Solid
溶解度 :
Soluble in water (30 mg/mL), and ethanol (>50 mg/mL).
保存 :
Store at -20° C
IC50 :
Iron-dependent lipid peroxidation: IC50 = 600 nM (rattus norvegicus)
pK值 :
pKa: 11.39, pKb: 12.04
仅供科研使用。不可用于诊断或治疗。
PubChem CID :
107656
SMILES :
CC1=C(C(=C2CCC(OC2=C1C)(C)CN3CCN(CC3)C4=NC(=NC(=C4)N5CCCC5)N6CCCC6)C)O.Cl.Cl

下载SDS

分析证明书

在PDF文件上阅读,打印和批注,Adobe阅读器是必须的

U-83836E  产品相关文献索引

看其他用户如何应用U-83836E.点击进入浏览PubMed条目 .

引用1 - 11

PMID: # 8589301  Salahudeen, A. et al. 1995. J. Am. Soc. Nephrol. 6: 1300-1303.

引用1 - 11
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 105ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 10ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

圣克鲁斯生物技术在生物医药研究市场的产品开发方面处于世界领先地位。欢迎 致电我们的免费电话1-800-457-3801。 版权 ©, 2007-2020圣克鲁斯生物技术。版权所有。“Santa Cruz Biotechnology”,圣克鲁斯生物技 术的 商标,“Santa Cruz Animal Health”,“San Juan Ranch”,“Supplement of Champions”,San Juan Ranch的商标,“Ultracruz”,“Chemcruz”,“Immunocruz”,“Exactacruz”和“EZ Touch”都是圣克鲁斯生物技术的注册商标。所有的商标都归其各自拥有者所有。