Molecular structure of U-74389G, CAS Number: 153190-29-5
U-74389G (CAS 153190-29-5)
See product citations (2)
Alternate Names:
21-(4-(2,6-di-1-Pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl)-pregna-1,4,9(11)-triene-3,20-dione (Z)-2-butenedioate
Application:
U-74389G is a potent inhibitor of superoxide-mediated lipid peroxidation
CAS Number:
153190-29-5
Purity:
≥98%
Molecular Weight:
726.9
Molecular Formula:
C37H50N6O2•C4H4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
U-74389G is a nonglucocorticoid 21-aminosteroid that acts as a potent inhibitor of superoxide-mediated lipid peroxidation and has strong antioxidant activity. The compound has particularly strong antioxidant activity in a membranous system, and can interact with and be transported across lipid membrane models. Studies show that U-74389G can inhibit lipid peroxidation in different experimental systems such as cultured brain microvessel endothelial cells, Cu2+ treated monocytic THP1 cells, and LLC-PK1 cell layers, where F2 isoprostane production is blocked by the compound. Research indicates that cold storage with addition of U-74389G helps preserve small intestinal mucosa.
U-74389G (CAS 153190-29-5) References
- In vitro evaluation of the antioxidant activity and biomembrane interaction of the lazaroid U-74389G. | Saija, A., et al. 2001. Life Sci. 68: 1351-66. PMID: 11388688
- Lazaroid (U-74389G) ameliorates lung injury due to lipid peroxidation and nitric oxide synthase-dependent reactive oxygen species generation caused by remote systematic ischemia-reperfusion following thoracoabdominal aortic occlusion. | Perlikos, F., et al. 2018. Int J Surg. 55: 156-161. PMID: 29860124
- Beneficial Effect of U-74389 G and Sildenafil in An Experimental Model of Flap Ischemia/Reperfusion Injury in Swine. Histological and Biochemical Evaluation of the Model. | Karamatsoukis, SL., et al. 2020. J Invest Surg. 33: 391-403. PMID: 30499737
- Lazaroid U-74389G in liver ischemia-reperfusion injury: A swine model. | Korontzi, MI., et al. 2019. Exp Ther Med. 18: 230-236. PMID: 31258658
- Pharmacological inhibition of lipid peroxidative damage by the 21-aminosteroid U-74389G improves cortical mitochondrial function following traumatic brain injury in young adult male rats. | Hill, RL., et al. 2020. Neuropharmacology. 170: 108023. PMID: 32142792
- The Effects of Ascorbic Acid and U-74389G on Renal Ischemia-Reperfusion Injury in a Rat Model. | Zografos, CG., et al. 2020. In Vivo. 34: 2475-2484. PMID: 32871775
- Correction to Improved survival and reversal of endothelial dysfunction by the 21-aminosteroid, U-74389G in splanchnic ischaemia-reperfusion injury in the rat. | . 2024. Br J Pharmacol. 181: 1690. PMID: 38570889
- 21-aminosteroid and 2-(aminomethyl)chromans inhibition of arachidonic acid-induced lipid peroxidation and permeability enhancement in bovine brain microvessel endothelial cell monolayers. | Shi, F., et al. 1995. Free Radic Biol Med. 19: 349-57. PMID: 7557549
- Copper-induced tissue factor expression in human monocytic THP-1 cells and its inhibition by antioxidants. | Crutchley, DJ. and Que, BG. 1995. Circulation. 92: 238-43. PMID: 7600656
- Improved small intestinal preservation after lazaroid U74389G treatment and cold storage in University of Wisconsin solution. | Katz, SM., et al. 1995. Transplantation. 59: 694-8. PMID: 7886794
- Hydrogen peroxide induces 21-aminosteroid-inhibitable F2-isoprostane production and cytolysis in renal tubular epithelial cells. | Salahudeen, A., et al. 1995. J Am Soc Nephrol. 6: 1300-3. PMID: 8589301
- Protection of ischemic and reperfused rat myocardium by the nonglucocorticoid 21-aminosteroid U-74389G, a new inhibitor of lipid peroxidation. | Campo, GM., et al. 1996. J Pharmacol Exp Ther. 277: 333-40. PMID: 8613938
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
U-74389G, 100 mg | sc-200804 | 100 mg | $108.00 |