Date published: 2025-9-5

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TREK-1 抗体 (F-6): sc-398449

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说明书
  • TREK-1 抗体 F-6 是小鼠单克隆 IgM κ,TREK-1抗体, 在11篇文献中引用,规格为200 µg/ml
  • 特异性抗原位于human物种的TREK-1的C-terminus附近的氨基酸354-380之间
  • 推荐用于 mouse, rat 和 human 来源的TREK-1 WB, IP, IF 和 ELISA检测
  • 关于如何获取TREK-1 (F-6): sc-398449免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgGκ BP-HRP是TREK-1 Antibody (F-6) 适用于 WB 应用。 的首选辅助检测试剂。该试剂现可与TREK-1 Antibody (F-6) 搭配使用(请参阅下面的订购信息)。有关其它 m-IgGκ BP 结合物,请参阅我们完整的小鼠 IgG 结合蛋白列表。

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関連項目

TREK-1抗体(F-6)是一种IgM κ小鼠单克隆TREK-1抗体(也称为TREK-1抗体),可通过WB、IP、IF和ELISA检测小鼠、大鼠和人类来源的TREK-1蛋白。TREK-1抗体(F-6)是非偶联的抗TREK-1抗体形式。TREK-1(也称为TWIK相关K+通道)和TREK-2是双孔K+通道家族的成员,属于机械敏感和脂肪酸刺激K+通道类。TREK-1具有外向整流的电流-电压关系,而TREK-2则表现出内向整流。TREK-1和TREK-2均可被花生四烯酸和其他天然存在的不饱和游离脂肪酸激活。这些家族成员具有两个形成孔的域和四个跨膜片段。TREK-2是一种由538个氨基酸组成的蛋白质,与TREK-1具有65%的氨基酸序列同源性。TREK-1在许多不同的组织中表达,特别是在肺和脑中,而TREK-2则主要在小脑、脾脏和睾丸中表达。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

TREK-1 抗体 (F-6) 参考文献:

  1. 机械敏感串联孔 K+ 通道家族的新成员 TREK-2  |  Bang, H., et al. 2000. J Biol Chem. 275: 17412-9. PMID: 10747911
  2. 电压依赖性钾通道的分子生物学。  |  Pongs, O. 1992. Physiol Rev. 72: S69-88. PMID: 1438587
  3. 心血管系统中的机械敏感TREK-1双孔域钾(K2P)通道。  |  Wiedmann, F., et al. 2021. Prog Biophys Mol Biol. 159: 126-135. PMID: 32553901
  4. 激活TREK-1(K2P2.1)钾通道可预防甲型流感引起的肺损伤。  |  Zyrianova, T., et al. 2023. Am J Physiol Lung Cell Mol Physiol. 324: L64-L75. PMID: 36410022
  5. 心脏中的TREK-1:潜在的生理和病理生理作用。  |  Bechard, E., et al. 2022. Front Physiol. 13: 1095102. PMID: 36620226
  6. TREK-1和TREK-2基因敲除小鼠对氟烷或异氟烷不具有抗药性。  |  Spencer, KA., et al. 2023. Anesthesiology. 139: 63-76. PMID: 37027798
  7. TWIK-1/TREK-1异二聚体的新型强效阻断剂作为潜在的抗抑郁药。  |  Lee, EH., et al. 2023. Biomed Pharmacother. 165: 115139. PMID: 37454597
  8. 钾通道及其不断演变的闸门。  |  Jan, LY. and Jan, YN. 1994. Nature. 371: 119-22. PMID: 8072541
  9. elegans 基因组计划揭示的八个钾通道家族。  |  Wei, A., et al. 1996. Neuropharmacology. 35: 805-29. PMID: 8938713
  10. 新型非常规外向整流 K+ 通道的克隆, 功能表达和脑定域。  |  Fink, M., et al. 1996. EMBO J. 15: 6854-62. PMID: 9003761
  11. 哺乳动物双孔机械门控 S 型 K+ 通道。  |  Patel, AJ., et al. 1998. EMBO J. 17: 4283-90. PMID: 9687497
  12. TRAAK 是一种哺乳动物神经元机械门控 K+ 通道。  |  Maingret, F., et al. 1999. J Biol Chem. 274: 1381-7. PMID: 9880510

订购信息

产品名称产品编号规格价格数量收藏夹

TREK-1 抗体 (F-6)

sc-398449
200 µg/ml
$316.00

TREK-1 (F-6): m-IgGκ BP-HRP 套装

sc-524345
200 µg Ab, 40 µg BP
$354.00

TREK-1 (F-6) 中和勝肽

sc-398449 P
100 µg/0.5 ml
$68.00

What application is the blocking peptide sc-398449 P appropriate for?

Asked by: DefinitelyNotMatt
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-08-23
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Rated 5 out of 5 by from Ottimi risultatiUsato in Western blotting su cellule derivate da tumore al seno umano MCF7 e T47D, ha dato un molto abbondante segnale delle dimensioni attese secondo il data sheet e la banda è risultata specifica e unica. Globalmente, il risultato è da ritenersi ottimo.
Date published: 2021-06-09
Rated 5 out of 5 by from Good antibodyI got the sample antibody from Santa Cruz and used it for ICC. It worked very nicely. I recommend to buy this product.
Date published: 2017-08-09
Rated 5 out of 5 by from Works well for IHC in mouse brainI was able to successfully use the monoclonal TREK-1 antibody to visualize the channels on endothelial cells in embryonic mouse brains. Tissue was fixed in 4% PFA and the antibody worked at 1:100-250 dilution.
Date published: 2017-04-11
Rated 5 out of 5 by from Great choice of antibody!This TREK-1 antibody is strong and reliable. Great WB results at 1:200 dilution.
Date published: 2017-01-13
Rated 5 out of 5 by from Produced positive Western blot data of TREKProduced positive Western blot data of TREK-1 expression in human hippocampus and human hypothalamus tissue extracts. -SCBT QC
Date published: 2014-01-19
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TREK-1 抗体 (F-6) is rated 5.0 out of 5 by 5.
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