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TNF-R1 Antibody (H398) - Western Blotting - Image 59812
TNF-R1 抗体 (H398): sc-52739. 293T 全细胞裂解液中 TNF-R1 表达的 Western 印迹分析.
TNF-R1 Antibody (H398) - Western Blotting - Image 59812
TNF-R1 抗体 (H398): sc-52739. 293T 全细胞裂解液中 TNF-R1 表达的 Western 印迹分析.
TNF-R1 抗体 (H398): sc-52739. 293T 全细胞裂解液中 TNF-R1 表达的 Western 印迹分析.

TNF-R1 抗体 (H398): sc-52739

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说明书
  • TNF-R1 抗体 H398 是小鼠单克隆 IgG2a, 在8篇文献中引用，提供 100 µg/ml
  • 针对HL-60 human急性早幼粒细胞白血病细胞系
  • 推荐用于 human 来源的the extracellular and soluble TNF-R1 receptors WB, IP, IF 和 FCM检测
  • 看 TNF-R1 (H-5): sc-8436，可查看有标记的 TNF-R1 抗体，包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • 目前，我们还没有完成TNF-R1 抗体 (H398)的首选二抗检测试剂的鉴定。这项工作正在进行中。
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関連項目

附加TNF-R抗体，包括TNF-R1和TNF-R2

肿瘤坏死因子（TNF）是一种多功能细胞因子，其功能通过两种不同的细胞表面受体来介导。这些受体分别被称为TNF-R1和TNF-R2，在大多数细胞类型上表达。TNF的大部分功能主要是通过TNF-R1介导的，而TNF-R2的信号传导则较少，仅限于免疫系统的细胞。这两种蛋白属于不断增长的TNF和神经生长因子（NGF）受体超家族，其中包括FAS、CD30、CD27和CD40。该超家族的成员是类型I膜蛋白，其序列同源性仅限于细胞外区域。TNF-R1与FAS以及三种结构不相关的信号蛋白TRADD、FADD和RIP）共享一种被称为"死亡结构域"的基序。这种"死亡结构域"是传导凋亡信号所必需的。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

TNF-R1 抗体 (H398) 参考文献:

  1. TRUSS, TNF-R1 和 TRPC 离子通道可协同逆转内质网 Ca2+ 储存减少对 m1 肌卡因乙酰胆碱受体信号的响应。  |  Mace, KE., et al. 2010. J Cell Physiol. 225: 444-53. PMID: 20458742
  2. TNF受体-1（TNF-R1）普遍存在的支架和信号蛋白通过N端对接界面与TNF-R1和TRAF2相互作用。  |  Terry Powers, JL., et al. 2010. Biochemistry. 49: 7821-9. PMID: 20704259
  3. TNF-α（-308G>A）和TNF-R1（36A>G）单核苷酸多态性是牙源性角化囊肿发生的强风险因素。  |  Ilic, B., et al. 2017. J Oral Pathol Med. 46: 292-296. PMID: 28199753
  4. 泛素化和蛋白水解在调节促凋亡和抗凋亡TNF-R1信号中的作用。  |  Fritsch, J., et al. 2017. Biochim Biophys Acta Mol Cell Res. 1864: 2138-2146. PMID: 28765050
  5. 乳腺腺癌样本中VEGF-R2和TNF-R1的表达和细胞因子生成，以及与这些恶性肿瘤组织病理学参数的相关性。  |  Autenshlyus, A., et al. 2018. Int J Immunopathol Pharmacol. 32: 2058738418787990. PMID: 29985074
  6. Kupffer细胞来源的TNF-α通过TNF-R1/Caspase 8触发ER应激导致肝星状细胞凋亡  |  Wang, WM., et al. 2020. Biomed Res Int. 2020: 8035671. PMID: 32802876
  7. NFL与AD患者血浆中的TNF-R1密切相关，但与认知能力下降无关。  |  Delaby, C., et al. 2021. Sci Rep. 11: 10283. PMID: 33986423
  8. 可溶性IL-6R、TNF-R1/2和细胞粘附分子血清水平在非转移性乳腺癌女性患者术前和辅助治疗中的预测作用：初步研究。  |  Bulska-Będkowska, W., et al. 2022. J Interferon Cytokine Res.. PMID: 36130158
  9. TNF-R1血浆水平升高预示着糖尿病冠心病患者急性缺血事件的发生。  |  Mas-Fontao, S., et al. 2024. Clin Investig Arterioscler.. PMID: 39343690
  10. (-)-表没食子儿茶素-3-没食子酸酯（EGCG）通过TNF-α/TNF-R1/NLRP3信号通路抑制炎症，从而改善卵蛋白诱导的哮喘。  |  Zhang, B., et al. 2025. Int Immunopharmacol. 144: 113708. PMID: 39626539

订购信息

产品名称产品编号规格价格数量收藏夹

TNF-R1 抗体 (H398)

sc-52739
100 µg/ml
$322.00

Can TNF-R1 (H398): sc-52739 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?

Asked by: jerojero
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent, TNF-R1 (H398): sc-52739 is available in a variety of direct conjugations, such as HRP, PE, FITC and AlexaFluors.
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by cmy0125 from Great features!This antibody works great in western blot analysis of TNF-R1 expression in Human cardiac fibroblasts cells.
Date published: 2022-11-01
Rated 5 out of 5 by jerojero from Excellent!This antibody works great in western blot analysis of TNF-R1 expression in 293T whole cell lysate.
Date published: 2017-02-06
Rated 4 out of 5 by CJ from Publishable data in WB using human CD4+ cellsPublishable data in WB using human CD4+ cells. -SCBT Publication Review
Date published: 2015-05-17
Rated 4 out of 5 by CJ from Band of interest seen in WB using 293T wholeBand of interest seen in WB using 293T whole cell lysate. -SCBT QC
Date published: 2015-05-08
Rated 4 out of 5 by SM from Publishable data in IF using human A549 cell linesPublishable data in IF using human A549 cell lines. -SCBT Publication Review
Date published: 2015-01-30
Rated 4 out of 5 by MS from Publishable data in CoIP using human A549Publishable data in CoIP using human A549 cell lines. -SCBT Publication Review
Date published: 2015-01-24
Rated 4 out of 5 by CJ from Publishable data in IHC using human primaryPublishable data in IHC using human primary keratinocytes. -SCBT Publication Review
Date published: 2013-05-19
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TNF-R1抗体 (H398) is rated 4.3 out of 5 by 7.
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