TMPyP4 CAS: 36951-72-1
MF: C44H38N8•C28H28O12S4
MW: 1363.60
A potent inhibitor of telomerase activity.

TMPyP4 (CAS 36951-72-1)

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同义词: meso-Tetra (N-methyl-4-pyridyl) porphine tetra tosylate
应用; A potent inhibitor of telomerase activity
CAS号码: 36951-72-1
纯度: ≥90%
分子量: 1363.60
分子式: C44H38N8•C28H28O12S4
* 参考分析证明 大量特定数据 (包括水 含量).
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TMPyP4, tetra-(N-methyl-4-pyridyl)porphyrin, is a potent inhibitor of human TERT (telomerase, IC50 = 6.5 μM). TMPyP4 binds strongly to DNA quadruplexes by stacking on the G-tetrads at the core of the quadruplex, resulting in telomerase inhibition. TMPyP4 fluoresces intensely in the presence of quadruplex DNA.


参考文献

1. Anantha, N.V., et al. 1998. Biochemistry. 37: 2709-2714. PMID: 9537740
2. Izbicka, E., et al. 1999. Cancer Res. 59: 639-644. PMID: 9973212
3. Shi, D.F., et al. 2001. J. Med. Chem. 44: 4509-4523. PMID: 11741471
4. Yamashita, T., et al. 2005. Bioorg. Med. Chem. 13: 2423-2430. PMID: 15755644

物理状态 :
Solid
溶解度 :
Soluble in water (1 mg/ml).
保存 :
Store at 4° C
IC50 :
telomerase: IC50 = 6.5 µM (human)
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
PubChem CID :
11979833
MDL 号码 :
MFCD00013468
Beilstein 注册 :
6049195
SMILES :
CC1=CC=C(C=C1)S(=O)(=O)[O-].CC1=CC=C(C=C1)S(=O)(=O)[O-].CC1=CC=C(C=C1)S(=O)(=O)[O-].CC1=CC=C(C=C1)S(=O)(=O)[O-].C[N+]1=CC=C(C=C1)C2=C3C=CC(=C(C4=CC=C(N4)C(=C5C=CC(=N5)C(=C6C=CC2=N6)C7=CC=[N+](C=C7)C)C8=CC=[N+](C=C8)C)C9=CC=[N+](C=C9)C)N3

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