Date published: 2025-9-9

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Thyroperoxidase 抗体 (MoAb47): sc-58432

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说明书
  • Thyroperoxidase抗体(MoAb47)是小鼠单克隆IgG1 κ, 在20篇文献中引用,规格为200 µg/ml
  • 与Thyroperoxidase反应,从human来源的甲状腺微粒体中纯化
  • 抗-Thyroperoxidase 抗体 (MoAb47) 推荐用于 WB, IP, IF 和 IHC(P),检测mouse, rat 和human 来源的 Thyroperoxidase
  • 抗Thyroperoxidase抗体(MoAb47)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取Thyroperoxidase (MoAb47): sc-58432免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRPm-IgG1 BP-HRP 是 Thyroperoxidase 抗体 (MoAb47) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与Thyroperoxidase 抗体 (MoAb47) 组合成套装提供。 (请参阅下面的订购信息)。

快捷链接

関連項目

甲状腺过氧化物酶抗体(MoAb47)是一种鼠单克隆IgG1 kappa轻链抗体,可通过蛋白质印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)和石蜡包埋切片免疫组织化学(IHCP)等方法检测小鼠、大鼠和人类样本中的甲状腺过氧化物酶。抗甲状腺过氧化物酶抗体(MoAb47)有非结合型和多种结合型,包括琼脂糖、辣根过氧化物酶(HRP)、藻红蛋白(PE)、异硫氰酸荧光素(FITC)和多种Alexa Fluor®结合物。甲状腺过氧化物酶(TPO)是合成甲状腺激素的关键酶,它促进甲状腺球蛋白中酪氨酸残基的碘化,而碘化对于甲状腺素(T4)和三碘甲状腺原氨酸(T3)的产生至关重要。这一过程对于调节脊椎动物的新陈代谢、生长和发育至关重要。TPO是一种933个氨基酸的第一型跨膜糖蛋白,它不仅在激素合成中起着重要作用,还是桥本氏甲状腺炎和格雷夫斯病等自身免疫性甲状腺疾病的主要自身抗原。TPO的结构包括一个大的N端髓过氧化物酶样结构域、一个补体控制蛋白结构域和一个表皮生长因子样结构域,这些结构域对于酶的活性和与其他蛋白的相互作用非常重要。此外,TPO还介导放射性碘的有机化和细胞内滞留,从而实现靶向肿瘤细胞死亡,凸显了潜在的治疗意义。TPO基因突变可导致先天性甲状腺功能减退症,其特点是碘化物有机化受损,这凸显了TPO在甲状腺功能和整体内分泌健康中的重要性。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Thyroperoxidase 抗体 (MoAb47) 参考文献:

  1. 人甲状腺过氧化物酶在内质网中的降解涉及两种不同的途径,取决于蛋白质的折叠状态。  |  Fayadat, L., et al. 2000. J Biol Chem. 275: 15948-54. PMID: 10748076
  2. 甲状腺过氧化物酶基因的异位表达会增强非小细胞肺癌患者对碘化钠交感神经介导的放射性碘的吸收和滞留。  |  Huang, M., et al. 2001. Cancer Gene Ther. 8: 612-8. PMID: 11571539
  3. 人类甲状腺过氧化物酶的多样性因替代剪接而不断增加。通过分子克隆具有单剪接和多剪接 mRNA 的新转录本确定其特征。  |  Ferrand, M., et al. 2003. J Biol Chem. 278: 3793-800. PMID: 12454013
  4. 桥本氏甲状腺炎患者通过 C4 与甲状腺过氧化物酶的直接结合激活补体。  |  Blanchin, S., et al. 2003. Endocrinology. 144: 5422-9. PMID: 12960013
  5. 甲状腺过氧化物酶向细胞表面的胞内运输。  |  Kuliawat, R., et al. 2005. J Biol Chem. 280: 27713-8. PMID: 15917231
  6. [慢性荨麻疹伴有甲状腺功能和甲状腺过氧化物酶抗体改变]。  |  Fernandez Romero, DS. and Malbran, A. 2005. Medicina (B Aires). 65: 231-4. PMID: 16042134
  7. 甲状腺过氧化物酶 T 细胞表位限制与人类白细胞抗原 DR3 转基因小鼠自身抗体免疫显性区的抗体识别之间的关系。  |  Guo, J., et al. 2005. Endocrinology. 146: 4961-7. PMID: 16081633
  8. 雌激素对正常大鼠和卵巢切除大鼠甲状腺碘化物摄取和甲状腺过氧化物酶活性的影响。  |  Lima, LP., et al. 2006. Steroids. 71: 653-9. PMID: 16762383
  9. 甲状腺自身免疫中的甲状腺过氧化物酶、甲状腺球蛋白、Na(+)/I(-)同向转运体、垂体素。  |  Czarnocka, B. 2011. Front Biosci (Landmark Ed). 16: 783-802. PMID: 21196203
  10. 左甲状腺素对亚临床甲状腺功能减退症和甲状腺过氧化物酶抗体阳性的复发性妊娠失败妇女妊娠结局的影响:系统回顾和荟萃分析。  |  Yu, M., et al. 2023. J Matern Fetal Neonatal Med. 36: 2233039. PMID: 37433649
  11. 药物治疗巴塞杜氏病中甲状腺过氧化物酶和甲状腺球蛋白抗体的意义。  |  Constantinescu, SM., et al. 2023. Eur Thyroid J. 12: PMID: 37930957
  12. 人类甲状腺过氧化物酶主要保留在内质网中并迅速降解。其 N-聚糖是折叠和细胞内运输所必需的。  |  Fayadat, L., et al. 1998. Endocrinology. 139: 4277-85. PMID: 9751510

订购信息

产品名称产品编号规格价格数量收藏夹

Thyroperoxidase 抗体 (MoAb47)

sc-58432
200 µg/ml
$316.00

Thyroperoxidase (MoAb47): m-IgG Fc BP-HRP 套装

sc-526906
200 µg Ab; 10 µg BP
$354.00

Thyroperoxidase (MoAb47): m-IgG1 BP-HRP 套装

sc-532279
200 µg Ab; 20 µg BP
$354.00

Thyroperoxidase 抗体 (MoAb47) AC

sc-58432 AC
500 µg/ml, 25% agarose
$416.00

Thyroperoxidase 抗体 (MoAb47) HRP

sc-58432 HRP
200 µg/ml
$316.00

Thyroperoxidase 抗体 (MoAb47) FITC

sc-58432 FITC
200 µg/ml
$330.00

Thyroperoxidase 抗体 (MoAb47) PE

sc-58432 PE
200 µg/ml
$343.00

Thyroperoxidase 抗体 (MoAb47) Alexa Fluor® 488

sc-58432 AF488
200 µg/ml
$357.00

Thyroperoxidase 抗体 (MoAb47) Alexa Fluor® 546

sc-58432 AF546
200 µg/ml
$357.00

Thyroperoxidase 抗体 (MoAb47) Alexa Fluor® 594

sc-58432 AF594
200 µg/ml
$357.00

Thyroperoxidase 抗体 (MoAb47) Alexa Fluor® 647

sc-58432 AF647
200 µg/ml
$357.00

Thyroperoxidase 抗体 (MoAb47) Alexa Fluor® 680

sc-58432 AF680
200 µg/ml
$357.00

Thyroperoxidase 抗体 (MoAb47) Alexa Fluor® 790

sc-58432 AF790
200 µg/ml
$357.00

I need to use an antibody to detect the protein in samples of non-mammalian origin. Do you know if this mouse monoclonal antibody will work?

Asked by: jerojero
Please contact our Technical Service Department and we would be happy to perform sequence analysis and review our data to answer any questions you may have about additional species reactivity.
Answered by: Technical Support 9
Date published: 2023-06-14

What is the recommended secondary reagent to be used with this mouse monoclonal primary?

Asked by: jerojero
We recommend using one our exclusive Mouse IgG Binding Proteins as a secondary detection reagent. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety
Answered by: Technical Support 9
Date published: 2017-01-11
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Rated 5 out of 5 by from good performanceThis antibody is good performance ,the antibody incubated at 4°C overnight, I see a target band at 100kda.The dilution can be 1:400 to 1:1000,this range dilution is no problem, it suitable for our detection.
Date published: 2017-08-12
Rated 5 out of 5 by from good for WB detectionThis antibody analysis in WB ,got strong band by 1:1000.
Date published: 2017-06-03
Rated 5 out of 5 by from Strong western dataVery nice western blot data; strong signal with low background
Date published: 2017-01-29
Rated 5 out of 5 by from Good for Western blottingThe Thyroperoxidase Antibody (MoAb47): sc-58432 provides good Western blot data showing clear band with minimal background. This antibody has been cited multiple times for further verificaiton.
Date published: 2017-01-12
Rated 4 out of 5 by from StrongStrong, specific band detected at expected molecular weight in human thyroid tissue extract. -SCBT QC
Date published: 2015-03-07
Rated 5 out of 5 by from This antibody was used in a publication onThis antibody was used in a publication on rat FRTL-5 cells, PC-12 cell line, and rat thyroid cells - SCBT Publication Review
Date published: 2015-01-17
Rated 4 out of 5 by from WB publishable data with human thyrocyteWB publishable data with human thyrocyte (primary culture) - SCBT Publication Review
Date published: 2013-01-21
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Thyroperoxidase 抗体 (MoAb47) is rated 4.7 out of 5 by 7.
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