Tenofovir CAS: 147127-20-6
MF: C9H14N5O4P
MW: 287.21
A selective HIV reverse transcriptase (HIV-1 RT) inhibitor.

Tenofovir (CAS 147127-20-6)

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同义词: Viread; PMPA; (R)-9-(2-Phosphonoylmethoxypropyl)adenine
应用; A selective HIV reverse transcriptase (HIV-1 RT) inhibitor
CAS号码: 147127-20-6
纯度: ≥98%
分子量: 287.21
分子式: C9H14N5O4P
* 参考分析证明 大量特定数据 (包括水 含量).
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Tenofovir is a selective antiretroviral agent which functions as a HIV reverse transcriptase inhibitor. Studies indicate that Tenofovir shows a low cytotoxicity in human cell types compared to other nucleoside reverse transcriptase inhibitors. It is known that HIV replicates its double stranded DNA via reverse transcriptase and then the DNA is integrated into the hosts chromosomes. Tenofovir functions by inhibiting the replication of this DNA. Furthermore, studies suggest that Tenofovir prevents cytoxicity in SIV-infected C-8166 cells in vitro.


参考文献

1. Tsai, C.C., et al. 1995. Science. 270: 1197-1199. PMID: 7502044
2. Van Rompay, K.K., et al. 1996. Antimicrob. Agents Chemother. 40: 2586-2591. PMID: 8913470
3. Cihlar, T., et al. 2002. Antiviral Res. 54: 37-45. PMID: 11888656

外观 :
Powder
物理状态 :
Solid
溶解度 :
Soluble in DMSO (10 mM), 1.1 eq.NaOH (100 mM), water (2 mg/ml at 25° C), and ethanol (<1 mg/ml at 25° C).
保存 :
Store at -20° C
熔点 :
480.00° C (Predicted)
沸点 :
~616.1° C at 760 mmHg
密度 :
~1.8 g/cm3 (Predicted)
折射率 :
n20D 1.74 (Predicted)
IC50 :
Hepatitis B virus: IC50 = 0.54 µM; Human immunodeficiency virus 1: IC50 = 0.82 µM; Hepatitis B virus: IC50 = 0.89 µM; Cytotoxicity in SIV-infected C-8166 cells: IC50 = 1.5 µM; Vaccinia virus: IC50 = 300 µM
pK值 :
pKa: 1.61 (Predicted), pKb: 4.22 (Predicted)
仅供科研使用。不可用于诊断或治疗。
RTECS :
SZ6563600
PubChem CID :
464205
MDL 号码 :
MFCD00943794
SMILES :
C[[email protected]](CN1C=NC2=C1N=CN=C2N)OCP(=O)(O)O

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引用1 - 99

PMID: # 30039346  Suter-Dick, L. et al. 2018. AAPS J. 20: 86.

PMID: # 27249967  Costa, S. et al. 2016. Parasitology research.

PMID: # 26779022  Mandíková, J. et al. 2015. Frontiers in pharmacology. 6: 304.

PMID: # 24906916  Chen, Z. et al. 2014. American journal of physiology. Heart and circulatory physiology. 307: H328-36.

PMID: # 24957831  2014. Antimicrobial agents and chemotherapy. 58: 5650-7.

PMID: # 24487230  Thein, P. et al. 2014. Hear. Res. 310: 27-35.

PMID: # 22499243  Gokulgandhi, MR. et al. 2012. Journal of pharmaceutical sciences. 101: 3249-63.

PMID: # 15280794  Edelstein, HE. et al. 2004. AIDS. 18: 1748-1749.

PMID: # 15280790  Saumoy, M. et al. 2004. AIDS. 18: 1741-1742.

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