TEMPOL CAS: 2226-96-2
MF: C9H18NO2
MW: 172.25
A superoxide dismutase mimetic that restores the effects of TNF-α.

TEMPOL (CAS 2226-96-2)

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同义词: 1-Oxyl-2,2,6,6-tetramethyl-4-hydroxypiperidine
应用; A superoxide dismutase mimetic that restores the effects of TNF-α
CAS号码: 2226-96-2
纯度: ≥99%
分子量: 172.25
分子式: C9H18NO2
* 参考分析证明 大量特定数据 (包括水 含量).
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TEMPOL is a superoxide dismutase mimetic that belongs to a class of non-thiol-containing radiation protectors, and has the ability to permeate the membrane. In the presence of TEMPOL, cerebral vessel remodeling is blocked and collagen IV mRNA expression levels are elevated in normotensive and hypertensive rat studies. TEMPOL has been shown to restore the oxidative stress and cardiac dysfunction induced by TNF-α and in PC-12 cells has revealed neuroprotective effects. Additionally, it has shown to decrease blood pressure and sympathetic nerve activity in DOCA-salt rat studies.


参考文献

1. Mitchell, J.B., et al. 1991. Arch. Biochem. Biophys. 289: 62-70. PMID: 1654848
2. Xu, H., et al. 2004. Hypertension. 43: 329-334. PMID: 14707156
3. Khattab, M.M., 2006. Eur. J. Pharmacol. 548: 167-173. PMID: 16973155
4. Lipman, T., et al. 2006. Eur. J. Pharmacol. 549: 50-57. PMID: 16989807
5. Mariappan, N., et al. 2007. Am. J. Physiol. Heart Circ. Physiol. 293: H2726-H2737. PMID: 17675574
6. Pires, P.W., et al. 2010. Microvasc Res. PMID: 20600163

外观 :
Crystalline
物理状态 :
Solid
溶解度 :
Soluble in water (1670 g/l) at 20° C, ethanol (100 mM), methanol, and DMSO (100 mM).
保存 :
Store at room temperature
熔点 :
69-71° C (lit.)
沸点 :
269° C
密度 :
1.19 g/cm3
IC50 :
Plasmodium falciparum K1: IC50 = 19 µg/ml; Plasmodium falciparum NF54: IC50 = 27 µg/ml
pK值 :
pKb: 5.15
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
1
RTECS :
TN8991000
PubChem CID :
137994
默克索引 :
14: 9141
MDL 号码 :
MFCD00006478
EC号码 :
218-760-9
Beilstein 注册 :
1422990
SMILES :
CC1(CC(CC(N1[O])(C)C)O)C

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引用1 - 1020

PMID: # 30718685  Kornienko, JS.|Smirnova, IS.|Pugovkina, NA.|Ivanova, JS.|Shilina, MA.|Grinchuk, TM.|Shatrova, AN.|Aksenov, ND.|Zenin, VV.|Nikolsky, NN.|Lyublinskaya, OG.| et al. 2019. Sci Rep. 9: 1296.

PMID: # 30990365  Thangaraj, A.|Periyasamy, P.|Guo, ML.|Chivero, ET.|Callen, S.|Buch, S.| et al. 2019. Autophagy.

PMID: # 30535505  Xu, TZ.|Shen, XY.|Sun, LL.|Chen, YL.|Zhang, BQ.|Huang, DK.|Li, WZ.| et al. 2018. Int. J. Mol. Med.

PMID: # 27069531  Salvi, A. et al. 2016. Oxid Med Cell Longev. 2016: 5059043.

PMID: # 27679544  Steiner, I. et al. 2016. Radiol Oncol. 50: 280-8.

PMID: # 27088800  Wen, Z. et al. 2016. J. Clin. Invest. 126: 1953-67.

PMID: # 27778515  Morita, K.|Miyazaki, S.|Numako, C.|Ikeno, S.|Sasaki, R.|Nishimura, Y.|Ogino, C.|Kondo, A.| et al. 2016. Free Radic. Res. 50: 1319-1328.

PMID: # 25793256  Patki, G. et al. 2015. PLoS ONE. 10: e0117498.

PMID: # 25752964  Al-Shboul, O. et al. 2015. Canadian journal of physiology and pharmacology. 93: 405-11.

PMID: # 26000607  Zhang, M. et al. 2015. PloS one. 10: e0127386.

引用1 - 1020
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