TCR α/β Antibody (3H2918): sc-73120

TCR α/β Antibody (3H2918) is a mouse monoclonal IgG1 antibody that detects T cell antigen receptor (TCR) in mouse and rat samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). TCR is a crucial component of the adaptive immune system, functioning primarily to recognize foreign antigens and initiate a cascade of intracellular signals that lead to T cell activation. This activation enables T cells to proliferate and differentiate into effector cells that can eliminate infected or malignant cells. TCR is a heterodimer, typically composed of either alpha and beta chains or gamma and delta chains, with the alpha/beta form being predominant in the majority of circulating T cells. The presence of CD3 chains and co-receptors such as CD4 or CD8 is essential for effective signal transduction through TCR, allowing T helper cells and T cytotoxic cells to be distinguished based on their expression of these co-receptors. CD4, also known as T4 or Leu 3, is a membrane glycoprotein that enhances the interaction between TCR and class II major histocompatibility complex (MHC) molecules presented by antigen-presenting cells, thereby increasing the avidity of the immune response. TCR α/β (3H2918) antibody is an invaluable tool for researchers studying T cell biology and the mechanisms of immune activation.

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TCR α/β Antibody (3H2918) References:

1. Signal transduction by the TCR for antigen.  |  Kane, LP., et al. 2000. Curr Opin Immunol. 12: 242-9. PMID: 10781399
2. Molecular determinants of TCR expression and selection.  |  Berg, LJ. and Kang, J. 2001. Curr Opin Immunol. 13: 232-41. PMID: 11228418
3. Immunotherapy through TCR gene transfer.  |  Kessels, HW., et al. 2001. Nat Immunol. 2: 957-61. PMID: 11577349
4. The TCR ADAPts to integrin-mediated cell adhesion.  |  Peterson, EJ. 2003. Immunol Rev. 192: 113-21. PMID: 12670399
5. Designing TCR for cancer immunotherapy.  |  Voss, RH., et al. 2005. Methods Mol Med. 109: 229-56. PMID: 15585925
6. Immunometabolism regulates TCR recycling and iNKT cell functions.  |  Fu, S., et al. 2019. Sci Signal. 12: PMID: 30808817
7. Exploiting TCR Recognition of Shared Hotspot Oncogene-encoded Neoantigens.  |  Olivera, I., et al. 2020. Clin Cancer Res. 26: 1203-1204. PMID: 32001482
8. CoV2-TCR: A web server for screening TCR CDR3 from TCR immune repertoire of COVID-19 patients and their recognized SARS-CoV-2 epitopes.  |  Jian, X., et al. 2023. Comput Struct Biotechnol J. 21: 1362-1371. PMID: 36741787
9. TCR clustering by contrastive learning on antigen specificity.  |  Pertseva, M., et al. 2024. Brief Bioinform. 25: PMID: 39129361
10. Crucial function of the pre-T-cell receptor (TCR) in TCR beta selection, TCR beta allelic exclusion and alpha beta versus gamma delta lineage commitment.  |  von Boehmer, H., et al. 1998. Immunol Rev. 165: 111-9. PMID: 9850856

The preferred TCR β antibody is TCR β Antibody (G-11): sc-5277.