TCP-1 η Antibody (C-6): sc-271439

TCP-1 η Antibody (C-6) is a mouse monoclonal IgG2b antibody that recognizes TCP-1 η in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TCP-1 η is a crucial subunit of the chaperonin containing TCP-1 (CCT) complex, which is essential for proper folding of cytosolic proteins, particularly actins and tubulins. TCP-1 η plays a significant role in maintaining cellular function by ensuring vital cytoskeletal components are correctly folded and assembled, which is critical for processes such as cell division, motility, and structural integrity. The CCT complex, composed of eight distinct subunits, including TCP-1 η, operates in a highly regulated manner to facilitate the folding of newly synthesized polypeptides, thereby preventing misfolding and aggregation that could lead to cellular dysfunction. TCP-1 η, along with its homologs, has been implicated in various cellular processes and is essential for the viability of eukaryotic cells, highlighting its importance in both normal physiology and disease states. With an ability to interact with multiple substrates, TCP-1 η serves as a key player in the cellular chaperone network, making anti-TCP-1 η antibody (C-6) an invaluable tool for researchers studying protein folding and related cellular mechanisms.

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TCP-1 η Antibody (C-6) References:

1. Chaperonin containing T-complex polypeptide subunit eta (CCT-eta) is a specific regulator of fibroblast motility and contractility.  |  Satish, L., et al. 2010. PLoS One. 5: e10063. PMID: 20442790
2. Intron sequences from the CCT7 gene exhibit diverse evolutionary histories among the four lineages within the Babesia microti-group, a genetically related species complex that includes human pathogens.  |  Fujisawa, K., et al. 2011. Jpn J Infect Dis. 64: 403-10. PMID: 21937822
3. Increased CCT-eta expression is a marker of latent and active disease and a modulator of fibroblast contractility in Dupuytren's contracture.  |  Satish, L., et al. 2013. Cell Stress Chaperones. 18: 397-404. PMID: 23292503
4. Regulation of GPCR expression through an interaction with CCT7, a subunit of the CCT/TRiC complex.  |  Génier, S., et al. 2016. Mol Biol Cell. 27: 3800-3812. PMID: 27708139
5. Requirement of Cellular Protein CCT7 for the Replication of Fowl Adenovirus Serotype 4 (FAdV-4) in Leghorn Male Hepatocellular Cells Via Interaction with the Viral Hexon Protein.  |  Gao, J., et al. 2019. Viruses. 11: PMID: 30691230
6. Urinary TCP1-eta: A Cortical Damage Marker for the Pathophysiological Diagnosis and Prognosis of Acute Kidney Injury.  |  Sancho-Martínez, SM., et al. 2020. Toxicol Sci. 174: 3-15. PMID: 31825490
7. Combined use of GM2AP and TCP1-eta urinary levels predicts recovery from intrinsic acute kidney injury.  |  Blanco-Gozalo, V., et al. 2020. Sci Rep. 10: 11599. PMID: 32665654
8. Clinical Significance, Cellular Function, and Potential Molecular Pathways of CCT7 in Endometrial Cancer.  |  Wang, L., et al. 2020. Front Oncol. 10: 1468. PMID: 32983981
9. Chaperonin TRiC/CCT subunit CCT7 is involved in the replication of canine parvovirus in F81 cells.  |  Su, X., et al. 2024. Front Microbiol. 15: 1346894. PMID: 38384266
10. Sequencing analysis of a 40.2 kb fragment of yeast chromosome X reveals 19 open reading frames including URA2 (5' end), TRK1, PBS2, SPT10, GCD14, RPE1, PHO86, NCA3, ASF1, CCT7, GZF3, two tRNA genes, three remnant delta elements and a Ty4 transposon.  |  Cziepluch, C., et al. 1996. Yeast. 12: 1471-4. PMID: 8948101

The preferred TCP-1 η antibody is TCP-1 η Antibody (A-8): sc-271951.