Date published: 2025-9-9
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TC-PTP Antibody (D-3) - Western Blotting - Image 311748
TC-PTP 抗体 (D-3): sc-398997. HeLa (A), NIH/3T3 (B), Hep G2 (C), Jurkat (D), CCRF-CEM (E) 和 HL-60 (F) 全细胞裂解液中 TC-PTP 表达的 Western 印迹分析.
TC-PTP Antibody (D-3) - Western Blotting - Image 311748
TC-PTP 抗体 (D-3): sc-398997. HeLa (A), NIH/3T3 (B), Hep G2 (C), Jurkat (D), CCRF-CEM (E) 和 HL-60 (F) 全细胞裂解液中 TC-PTP 表达的 Western 印迹分析.
TC-PTP Antibody (D-3) - Western Blotting - Image 357129
TC-PTP 抗体 (D-3): sc-398997. F9 全细胞裂解液中 TC-PTP 表达的 Western 印迹分析.
TC-PTP Antibody (D-3) - Western Blotting - Image 357117
TC-PTP 抗体 (D-3): sc-398997. 在 NIH/3T3 全细胞裂解液中检测 TC-PTP 表达的 Western 印迹分析.
TC-PTP 抗体 (D-3): sc-398997. HeLa (A), NIH/3T3 (B), Hep G2 (C), Jurkat (D), CCRF-CEM (E) 和 HL-60 (F) 全细胞裂解液中 TC-PTP 表达的 Western 印迹分析.

TC-PTP 抗体 (D-3): sc-398997

5.0(1)
寫評論提問

说明书
  • TC-PTP抗体(D-3)是小鼠单克隆IgM (kappa轻链)，规格为200 µg/ml
  • 特异性抗原位于human物种的TC-PTP的内部区域内的氨基酸291-312之间
  • 推荐用于 mouse, rat 和 human 来源的TC-PTP WB, IP, IF 和 ELISA检测
  • 目前，我们还没有完成TC-PTP 抗体 (D-3)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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    描述
    基因信息
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    関連項目

    T细胞蛋白酪氨酸磷酸酶（TC-PTP）是一种非跨膜酶。TC-PTP的非催化结构域通过选择性剪接产生p45TC，它定位于细胞核，而p48TC包含一个疏水的C端尾部并定位于内质网。p45TC的C端片段通过分子内相互作用调节催化结构域的活性。当EGF受体被激活时，TC-PTP的p45TC变体从细胞核中出来，并识别EGF受体和p52Shc细胞底物。p45TC的活性几乎完全抑制了EGF依赖性PI 3-激酶和PKB/Akt的激活。在胶质母细胞瘤细胞中，p45TC变体抑制DEGFR介导的ERK2的激活，并在体内抑制肿瘤发生。TC-PTP可能在淋巴细胞信号转导和造血稳态中发挥作用。TC-PTP对JAK1和JAK3具有负调节作用，TC-PTP缺陷小鼠在造血系统中显示出严重缺陷。编码人类TC-PTP的基因位于18号染色体上。

    仅限研究使用。不适用于诊断和治疗用途。

    订购信息

    产品名称产品编号规格价格数量收藏夹

    TC-PTP 抗体 (D-3)

    sc-398997
    200 µg/ml
    		$316.00

    TC-PTP (D-3) 中和勝肽

    sc-398997 P
    100 µg/0.5 ml
    		$68.00

    Hi, what kind of 2nd antibody can be used for sc-398997 since it is IgM(kappa light chain)? And if I have a secondary antibody which is anti-IgM(heavy chain) can I used for the sc-398997?

    Asked by: Dylan L
    Thank you for your question. Anti-Mouse IgG Kappa Binding Proteins such as m-IgGκ BP-HRP: sc-516102 or m-IgGκ BP-CFL 488: sc-516176 recognize both kappa IgG and kappa IgM mouse primary antibodies.
    Answered by: Tech Support Europe
    Date published: 2022-09-30

    What application is the blocking peptide sc-398997 P appropriate for?

    Asked by: Cweed
    Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
    Answered by: Technical Support
    Date published: 2017-02-27
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    Rated 5 out of 5 by from Very good Western blot data of TCVery good Western blot data of TC-PTP expression in HeLa, NIH/3T3, Hep G2, Jurkat, CCRF-CEM and HL-60 whole cell lysates. -SCBT QC
    Date published: 2014-09-07
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    TC-PTP 抗体 (D-3) is rated 5.0 out of 5 by 1.
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