TBL1 Antibody (A-3): sc-137082

TBL1 Antibody (A-3) is a mouse monoclonal IgG1 antibody that detects TBL1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TBL1, or transducin β-like 1, plays a pivotal role in the regulation of gene expression by functioning as a co-regulator in the nuclear receptor signaling pathway. TBL1 is essential for the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units, thereby influencing the transcriptional activity of various genes. TBL1 is characterized by its six β-transducin repeats, which are critical for its interaction with other proteins, including histones H2B, H3a, and H4, facilitating chromatin remodeling and gene activation. The importance of TBL1 in cellular processes is underscored by its involvement in the N-CoR repressor complex, which includes other key components such as N-CoR1, N-CoR2, and HDAC3, highlighting its role in maintaining proper transcriptional regulation. Defects in TBL1X, one of its isoforms, are linked to ocular albinism with late-onset sensorineural deafness, illustrating the clinical significance of TBL1. TBL1 (A-3) antibody is an invaluable tool for researchers studying the intricate mechanisms of gene regulation and the functional implications of TBL1 in various biological contexts.

The preferred TBL1 antibody is TBL1 Antibody (H-3): sc-137006.