TAPBPL Antibody (42-L): sc-100290

TAPBPL Antibody (42-L) is a mouse monoclonal IgG2a kappa light chain antibody that detects TAPBPL protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-TAPBPL antibody (42-L) is available as a non-conjugated format. TAPBPL, also known as TAPBPR or TAPBP-R, is a 468 amino acid protein characterized by one immunoglobulin-like C1-type domain and one immunoglobulin-like V-type domain. TAPBPL (42-L) antibody recognizes a protein localized to endoplasmic reticulum (ER) and microsome membranes, functioning as a single-pass type I membrane protein. Structural similarity to TPN (TAP binding protein) suggests TAPBPL may play a crucial role in antigen processing within the ER, particularly in loading peptides onto major histocompatibility complex (MHC) class I molecules. This function is vital for immune response, ensuring effective recognition and response to pathogens. TAPBPL interaction with TPN and other proteins involved in antigen presentation highlights its importance in maintaining immune surveillance and response, making TAPBPL a significant target for research in immunology and related fields.

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TAPBPL Antibody (42-L) References:

1. Is tapasin a modified Mhc class I molecule?  |  Mayer, WE. and Klein, J. 2001. Immunogenetics. 53: 719-23. PMID: 11862402
2. A human TAPBP (TAPASIN)-related gene, TAPBP-R.  |  Teng, MS., et al. 2002. Eur J Immunol. 32: 1059-68. PMID: 11920573
3. Direct peptide-regulatable interactions between MHC class I molecules and tapasin.  |  Rizvi, SM. and Raghavan, M. 2006. Proc Natl Acad Sci U S A. 103: 18220-5. PMID: 17116884
4. Formation of a major histocompatibility complex class I tapasin disulfide indicates a change in spatial organization of the peptide-loading complex during assembly.  |  Chambers, JE., et al. 2008. J Biol Chem. 283: 1862-9. PMID: 18039656
5. TAPBPR isoforms exhibit altered association with MHC class I.  |  Porter, KM., et al. 2014. Immunology. 142: 289-99. PMID: 24444341
6. Structural aspects of chaperone-mediated peptide loading in the MHC-I antigen presentation pathway.  |  Natarajan, K., et al. 2019. Crit Rev Biochem Mol Biol. 54: 164-173. PMID: 31084439
7. Identification of TAPBPL as a novel negative regulator of T-cell function.  |  Lin, Y., et al. 2021. EMBO Mol Med. 13: e13404. PMID: 33938620
8. Combination of Immune-Related Network and Molecular Typing Analysis Defines a Three-Gene Signature for Predicting Prognosis of Triple-Negative Breast Cancer.  |  Zhang, J., et al. 2022. Biomolecules. 12: PMID: 36358906
9. Identification of novel drug targets for multiple sclerosis by integrating plasma genetics and proteomes.  |  Liu, Y., et al. 2024. Exp Gerontol. 194: 112505. PMID: 38964432
10. Roles for calreticulin and a novel glycoprotein, tapasin, in the interaction of MHC class I molecules with TAP.  |  Sadasivan, B., et al. 1996. Immunity. 5: 103-14. PMID: 8769474
11. A critical role for tapasin in the assembly and function of multimeric MHC class I-TAP complexes.  |  Ortmann, B., et al. 1997. Science. 277: 1306-9. PMID: 9271576
12. Genomic analysis of the Tapasin gene, located close to the TAP loci in the MHC.  |  Herberg, JA., et al. 1998. Eur J Immunol. 28: 459-67. PMID: 9521053

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TAPBPL Antibody (42-L) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-TAPBPL Antibody (42-L) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TAPBPL Antibody (42-L) Specifications

Alternate Product Name: TAPBPL

Product Clone Name: 42-L

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 23-122

Epitope Target: TAPBPL

Epitope Species: human

Product Reactivity/Detection: TAPBPL

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for TAPBPL Antibody (42-L): N/A