Date published: 2025-9-7
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Tak1 Antibody (C-9) - Western Blotting - Image 376150
Tak1 抗体 (C-9): sc-7967. HeLa (A), K-562 (B), F9 (C) 和 U-698-M (D) 全细胞裂解液中 Tak1 表达的 Western 印迹分析.
Tak1 抗体 (C-9): sc-7967. HeLa (A), K-562 (B), F9 (C) 和 U-698-M (D) 全细胞裂解液中 Tak1 表达的 Western 印迹分析.

Tak1 抗体 (C-9): sc-7967

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说明书
  • Tak1 抗体 C-9 是小鼠单克隆 IgG2a κ，Tak1抗体, 在66篇文献中引用，规格为200 µg/ml
  • 针对氨基酸1-579的抗原，代表全长Tak1（TGFβ激活激酶），mouse起源
  • Tak1 抗体 (C-9) 推荐用于 WB, IP, IF 和 ELISA，检测mouse, rat 和human 来源的 Tak1
  • 抗Tak1抗体（C-9）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取Tak1 (C-9): sc-7967的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP和m-IgGκ BP-HRP是Tak1 Antibody (C-9) 适用于 WB 应用。 的首选辅助检测试剂，这些试剂现与Tak1 Antibody (C-9) 打包提供（请参阅下面的订购信息）。

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描述
基因信息
蛋白序列
说明书与实验方案
研究信息

関連項目

额外抗体，包括Tak1L

Tak1抗体（C-9）是一种小鼠单克隆IgG2a kappa kappa轻链抗体，针对小鼠Tak1（TGFβ激活的激酶1）的氨基酸1-579，也称为MAP3K7（促分裂原活化蛋白激酶7）。Tak1 单克隆抗体（C-9）可通过蛋白质印迹（WB）、免疫沉淀（IP）、免疫荧光（IF）和酶联免疫吸附测定（ELISA）检测小鼠、大鼠和人类来源的 Tak1 蛋白。Tak1是一种丝氨酸/苏氨酸激酶，在细胞对TGFβ和白细胞介素1（IL-1）等细胞因子的反应中发挥关键作用，激活下游NF-κB和MAP激酶信号通路，这些信号通路对于炎症、免疫反应、细胞存活和凋亡至关重要。Tak1功能失调与多种病理状况有关，包括癌症和炎症性疾病，因此Tak1成为生物医学研究的重要靶标。Tak1 单克隆抗体（C-9）可用于研究关键信号通路及其在疾病机理中的作用。Tak1 单克隆抗体（C-9）有非结合型和多种结合型，包括琼脂糖、HRP、PE、FITC 和几种 Alexa Fluor® 结合物，便于在研究中实现多种应用。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Tak1 抗体 (C-9) 参考文献:

  1. 减数分裂和有丝分裂细胞周期控制中的蛋白激酶级联。  |  Pelech, SL., et al. 1990. Biochem Cell Biol. 68: 1297-330. PMID: 2085430
  2. 从膜到细胞质的信号转导：生长因子和膜结合的癌基因产物会增加 Raf-1 磷酸化和相关蛋白激酶的活性。  |  Morrison, DK., et al. 1988. Proc Natl Acad Sci U S A. 85: 8855-9. PMID: 3057494
  3. 胰岛素刺激的微管相关蛋白激酶在体内被酪氨酸和苏氨酸磷酸化。  |  Ray, LB. and Sturgill, TW. 1988. Proc Natl Acad Sci U S A. 85: 3753-7. PMID: 3287375
  4. TAK1 在蛛网膜下腔出血后早期脑损伤中介导神经元热解。  |  Xu, P., et al. 2021. J Neuroinflammation. 18: 188. PMID: 34461942
  5. 小鼠 A-raf 的特征，这是一种与 v-raf 癌基因相关的新的癌基因。  |  Huleihel, M., et al. 1986. Mol Cell Biol. 6: 2655-62. PMID: 3491291
  6. TAK1在RANKL诱导的破骨细胞形成中的作用。  |  Jianwei, W., et al. 2022. Calcif Tissue Int. 111: 1-12. PMID: 35286417
  7. TAK1缺乏通过铁死亡和巨噬细胞cGAS-STING信号传导促进肝损伤和肿瘤发生。  |  Su, W., et al. 2023. JHEP Rep. 5: 100695. PMID: 36968217
  8. TAK1是STING运输的重要激酶。  |  Ma, M., et al. 2023. Mol Cell. 83: 3885-3903.e5. PMID: 37832545
  9. KSR：RAS 通路中的新型参与者。  |  Downward, J. 1995. Cell. 83: 831-4. PMID: 8521506
  10. KSR，一种 RAS 信号转导所需的新型蛋白激酶。  |  Therrien, M., et al. 1995. Cell. 83: 879-88. PMID: 8521512
  11. elegans ksr-1 基因编码一种参与 Ras 介导的信号转导的新型 Raf 相关激酶。  |  Sundaram, M. and Han, M. 1995. Cell. 83: 889-901. PMID: 8521513
  12. 确定 MAPKKK 家族的一个成员是 TGF-beta 信号转导的潜在媒介。  |  Yamaguchi, K., et al. 1995. Science. 270: 2008-11. PMID: 8533096

订购信息

产品名称产品编号规格价格数量收藏夹

Tak1 抗体 (C-9)

sc-7967
200 µg/ml
$316.00

Tak1 (C-9): m-IgG Fc BP-HRP 套装

sc-528190
200 µg Ab; 10 µg BP
$354.00

Tak1 (C-9): m-IgGκ BP-HRP 套装

sc-520512
200 µg Ab, 40 µg BP
$354.00

Tak1 抗体 (C-9) AC

sc-7967 AC
500 µg/ml, 25% agarose
$416.00

Tak1 抗体 (C-9) HRP

sc-7967 HRP
200 µg/ml
$316.00

Tak1 抗体 (C-9) FITC

sc-7967 FITC
200 µg/ml
$330.00

Tak1 抗体 (C-9) PE

sc-7967 PE
200 µg/ml
$343.00

Tak1 抗体 (C-9) Alexa Fluor® 488

sc-7967 AF488
200 µg/ml
$357.00

Tak1 抗体 (C-9) Alexa Fluor® 546

sc-7967 AF546
200 µg/ml
$357.00

Tak1 抗体 (C-9) Alexa Fluor® 594

sc-7967 AF594
200 µg/ml
$357.00

Tak1 抗体 (C-9) Alexa Fluor® 647

sc-7967 AF647
200 µg/ml
$357.00

Tak1 抗体 (C-9) Alexa Fluor® 680

sc-7967 AF680
200 µg/ml
$357.00

Tak1 抗体 (C-9) Alexa Fluor® 790

sc-7967 AF790
200 µg/ml
$357.00

I am using the LiCor/Odyssey system. Which secondary antibody do you recommend using with Tak1 Antibody (C-9): sc-7967?

Asked by: TinTin
We recommend using one of our our exclusive Mouse IgG Binding Proteins (m-IgGκ) conjugated to CFL 680 or CFL 790. They are suitable for use with Near-Infrared (NIR) detection systems, such as LI-COR/Odyssey and other comparable systems. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety
Answered by: Technical Support 13
Date published: 2017-01-09
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Rated 1 out of 5 by from It did not workI used this antibody 1:1000 in whole lysate mouse A/J cells for WB. No bands showed up on the predicted size. Just a non-specific one at around 50kDa.
Date published: 2019-06-06
Rated 1 out of 5 by from Tak1 Antibody (C-9)I used whole heart homogenates for this WB. No bands showed up on the predicted size. Just a non-specific one at around 50kDa.
Date published: 2017-12-05
Rated 4 out of 5 by from Good mouse monoclonal antibodyTak1 is involved in many different signaling pathways. We investigated Tak1 implication in inflammatory signaling. In particular in NF-kB activation after LPS triggering. This antibody works good for WB application.
Date published: 2017-11-20
Rated 2 out of 5 by from Did not work for IP in human cellsAntibody did not work for IP of TAK1 from human airway smooth muscle cell lysates. Also, did not produce a band in Western blot using total cell lysates but the levels are probably too low to detect without IP.
Date published: 2017-11-02
Rated 4 out of 5 by from It is excellent for WBGet good Western blot and clean band at expected size
Date published: 2017-07-21
Rated 5 out of 5 by from Good resultsThe results look very good in WB at 1:1000 when I used the human cells
Date published: 2017-07-12
Rated 3 out of 5 by from Not greatest for IF stainingReceived sample and tried to use for IF staining but didn't turn out very well. Not great signal and high background.
Date published: 2017-05-18
Rated 5 out of 5 by from appropriate dilution ratioStrong bands detected in WB when using K-562 whole cell lysates
Date published: 2017-05-12
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Tak1 抗体 (C-9) is rated 3.4 out of 5 by 14.
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