Syk Inhibitor IV, BAY 61-3606 HCl CAS: 732983-37-8
MF: C20H18N6O3•HCl
MW: 426.86

Syk Inhibitor IV, BAY 61-3606 HCl (CAS 732983-37-8)

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Syk Inhibitor IV, BAY 61-3606 HCl is rated 5.0 out of 5 by 1.
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备用名: BAY 61-3606; 2-(7-(3,4-Dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino)-nicotinamide HCl
应用; Syk Inhibitor IV, BAY 61-3606 HCl is an imidazopyrimidine inhibitor of Syk and Syk-mediated functions
CAS号码: 732983-37-8
纯度: ≥97%
分子量: 426.86
分子式: C20H18N6O3•HCl
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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Syk Inhibitor IV, BAY 61-3606 (BAY 61-3606) is a cell-permeable imidazopyrimidine compound that acts as a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (Ki = 7.5 nM) with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src. BAY 61-3606 has been shown to inhibit Syk-mediated cellular functions such as inhibition of high glucose-tyrosine phosphorylation of I κ B α and p65 nuclear translocation. In mast cells BAY 61-3606 has inhibited cytokine synthesis, lipid mediation and degranulation. In addition, monocyte and eosinophil activation by B cells and Fc receptors were suppressed by BAY 61-3606.


参考文献

1. Yamamoto, N., et al. 2003. J. Pharm. Exp. Ther. 306:1174-1181. PMID: 12766258
2. Yang, W.S., et al. 2008. Am. J. Physiol. Renal Physiol. 294: F1065-F1075. PMID: 18353872

物理状态 :
Solid
溶解度 :
Soluble in DMSO (10 mg/ml), water (20 mg/ml), and methanol.
保存 :
Store at 4° C
IC50 :
Syk tyrosine kinase activity: IC50 = 10 nM
Ki 数据 :
Syk tyrosine kinase activity: Ki= 7.5 nM
仅供科研使用。不可用于诊断或治疗。
PubChem CID :
MDL 号码 :
MFCD18641826
SMILES :
C1=C(C=CC(=C1OC)OC)C3=CC2=NC=C[N]2C(=N3)NC4=NC=CC=C4C(N)=O.Cl

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PMID: # 34603335  Liu, R.|Liu, Y.|Liu, C.|Gao, A.|Wang, L.|Tang, H.|Wu, Q.|Wang, X.|Tian, D.|Qi, Z.|Shen, Y.| et al. 2021. Front Immunol. 12: 747370.

PMID: # 33691478  Xu, Z.|Liang, Y.|Delaney, MK.|Zhang, Y.|Kim, K.|Li, J.|Bai, Y.|Cho, J.|Ushio-Fukai, M.|Cheng, N.|Du, X.| et al. 2021. Arterioscler Thromb Vasc Biol. ATVBAHA120315773.

PMID: # 33805059  Haschemi, R.|Gockel, LM.|Bendas, G.|Schlesinger, M.| et al. 2021. Int J Mol Sci. 22:

PMID: # 33938187  Pan, S.|Lee, E.|Lee, YJ.|Jin, M.|Lee, E.| et al. 2021. Allergol Immunopathol (Madr). 49: 42-49.

PMID: # 28949404  Unsal, D.|Kacan, M.|Temiz-Resitoglu, M.|Guden, DS.|Korkmaz, B.|Sari, AN.|Buharalioglu, CK.|Yildirim-Yaroglu, H.|Tamer-Gumus, L.|Tunctan, B.|Malik, KU.|Sahan-Firat, S.| et al. 2018. Clin. Exp. Pharmacol. Physiol. 45: 155-165.

PMID: # 29901140  Qiao, Y. et al. 2018. Mol Med Rep. 18: 1995-2008.

PMID: # 30104977  Ji, N.|Pan, S.|Shao, C.|Chen, Y.|Zhang, Z.|Wang, R.|Qiu, Y.|Jin, M.|Kong, D.| et al. 2018. Front Pharmacol. 9: 824.

PMID: # 26619766  Vandenbriele, C. et al. 2016. Platelets. 27: 365-72.

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PMID: # 25543269  Kremlitzka, M. et al. 2015. Cellular and molecular life sciences : CMLS. 72: 2223-36.

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