Date published: 2025-9-7

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StAR 抗体 (D-2): sc-166821

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说明书
  • StAR 抗体 D-2 是小鼠单克隆 IgG1 κ,StAR抗体, 在38篇文献中引用,规格为200 µg/ml
  • 免疫human物种的代表全长StAR的氨基酸1-285
  • StAR 抗体 (D-2) 推荐用于 WB, IP, IF 和 ELISA,检测mouse, rat 和human 来源的 StAR
  • 抗StAR抗体(D-2)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取StAR (D-2): sc-166821免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP1 BP-HRP">m-IgG1 BP-HRPm-IgGκ BP-HRP是StAR Antibody (D-2) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与StAR Antibody (D-2) 打包提供(请参阅下面的订购信息)。

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関連項目

StAR抗体(D-2)是一种IgG1 κ型小鼠单克隆StAR抗体(也称为STARD1抗体、StAR相关脂质转移(START)域包含1抗体或类固醇生成急性调节蛋白抗体),通过WB、IP、IF和ELISA检测小鼠、大鼠和人源StAR蛋白。StAR Antibody (D-2)既可以是抗StAR抗体的非偶联形式,也可以是多种偶联形式的抗StAR抗体,包括琼脂糖,HRP, PE, FITC和多个Alexa Fluor®偶联物。类固醇生成急性调节(StAR)蛋白似乎可介导受促性激素刺激的孕烯醇酮合成的快速增加。StAR增加孕烯醇酮的合成超过4倍,在卵巢和睾丸中发现一个1.6 kb的主要StAR转录本。在卵巢卵泡的持续生长和分化过程中,StAR的免疫反应性倾向于从早期窦状卵泡的颗粒细胞转移到成年卵泡膜细胞层。类固醇生成的第一步也是限速步骤是胆固醇从线粒体外膜转移到内膜,在那里它通过细胞色素P450侧链裂解转化为孕烯醇酮。这种反应在性腺和肾上腺中由StAR调节,然而,StAR的作用机制尚不清楚。该蛋白是从人类肾上腺皮质文库中分离出来的,StAR基因的无义突变可导致类脂质性先天性肾上腺增生。编码StAR的基因定位于人类染色体8p11.2。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

StAR 抗体 (D-2) 参考文献:

  1. 大鼠卵泡分化过渡阶段类固醇生成急性调节蛋白的免疫定位和表达。  |  Thompson, WE., et al. 1999. J Histochem Cytochem. 47: 769-76. PMID: 10330453
  2. 胆固醇是否利用线粒体接触点作为通往类固醇生成途径的通道?  |  Thomson, M. 2003. Bioessays. 25: 252-8. PMID: 12596229
  3. 大脑中的类固醇生成急性调节蛋白。  |  Lavaque, E., et al. 2006. Neuroscience. 138: 741-7. PMID: 16338087
  4. 一种新型线粒体胆固醇转运蛋白--类固醇生成急性调节蛋白(StAR)。  |  Miller, WL. 2007. Biochim Biophys Acta. 1771: 663-76. PMID: 17433772
  5. 类固醇生成急性调节蛋白是莱狄格细胞和性脊柱间质瘤的有效标记物。  |  Dong, L., et al. 2011. Appl Immunohistochem Mol Morphol. 19: 226-32. PMID: 21217523
  6. 类固醇生成急性调节蛋白在健康和疾病中的作用。  |  Manna, PR., et al. 2016. Endocrine. 51: 7-21. PMID: 26271515
  7. 缺陷的内部变构网络导致蛋白激酶A致癌嵌合体的ATP/底物结合协同作用失调。  |  Zhou, W., et al. 2016. PLoS One. 11: e0162606. PMID: 27606678
  8. 类固醇生成急性调节蛋白:结构、功能和调节。  |  Tugaeva, KV. and Sluchanko, NN. 2019. Biochemistry (Mosc). 84: S233-S253. PMID: 31213205
  9. 类固醇生成急性调节蛋白/醛固酮合酶介导血管紧张素 II 诱导的心脏纤维化和肥大。  |  Zhang, WW., et al. 2020. Mol Biol Rep. 47: 1207-1222. PMID: 31820314
  10. 人类类固醇生成急性调节蛋白:在 COS-1 细胞中的功能活性, 组织特异性表达以及结构基因在 8p11.2 和假基因在 13 号染色体上的图谱。  |  Sugawara, T., et al. 1995. Proc Natl Acad Sci U S A. 92: 4778-82. PMID: 7761400
  11. 类固醇生成急性调节蛋白在肾上腺和性腺类固醇生成中的作用  |  Lin, D., et al. 1995. Science. 267: 1828-31. PMID: 7892608
  12. 类固醇生成急性调节蛋白(StAR)在类固醇生成中的作用。  |  Stocco, DM. and Clark, BJ. 1996. Biochem Pharmacol. 51: 197-205. PMID: 8573184

订购信息

产品名称产品编号规格价格数量收藏夹

StAR 抗体 (D-2)

sc-166821
200 µg/ml
$316.00

StAR (D-2): m-IgG Fc BP-HRP 套装

sc-529059
200 µg Ab; 10 µg BP
$354.00

StAR (D-2): m-IgGκ BP-HRP 套装

sc-521758
200 µg Ab, 40 µg BP
$354.00

StAR (D-2): m-IgG1 BP-HRP 套装

sc-543295
200 µg Ab; 20 µg BP
$354.00

StAR 抗体 (D-2) AC

sc-166821 AC
500 µg/ml, 25% agarose
$416.00

StAR 抗体 (D-2) HRP

sc-166821 HRP
200 µg/ml
$316.00

StAR 抗体 (D-2) FITC

sc-166821 FITC
200 µg/ml
$330.00

StAR 抗体 (D-2) PE

sc-166821 PE
200 µg/ml
$343.00

StAR 抗体 (D-2) Alexa Fluor® 488

sc-166821 AF488
200 µg/ml
$357.00

StAR 抗体 (D-2) Alexa Fluor® 546

sc-166821 AF546
200 µg/ml
$357.00

StAR 抗体 (D-2) Alexa Fluor® 594

sc-166821 AF594
200 µg/ml
$357.00

StAR 抗体 (D-2) Alexa Fluor® 647

sc-166821 AF647
200 µg/ml
$357.00

StAR 抗体 (D-2) Alexa Fluor® 680

sc-166821 AF680
200 µg/ml
$357.00

StAR 抗体 (D-2) Alexa Fluor® 790

sc-166821 AF790
200 µg/ml
$357.00

Dear Madam/ Sir, I would like to ask you for a test sample of sc-166821: StAR (D-2) monoclonal antibody. Thank you in advance. Looking forward to hearing from you. Kind regardS

Asked by: PAK67
Thank you for your interest in our StAR antibody sc-166821. For samples and availability, please contact our European Technical Service team. You can reach them by phone at Toll Free: +49 6221 4503 0, by email at: europe@scbt.com or by live chat directly on our website, www.scbt.com
Answered by: Technical Service
Date published: 2017-04-20

What is the recommended starting dilution for Western blot for sc-166821: StAR (D-2) monoclonal antibody?

Asked by: Professor Griffin
The recommended starting dilution for Western blot is 1:100 with a dilution range of 1:100-1:1000. This information, along with other technical specifications, is available in the recommended protocol: https://www.scbt.com/scbt/resources/protocols/western-immuno-blotting
Answered by: Technical Support
Date published: 2017-03-22
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Rated 5 out of 5 by from clear bandExactly clear band in right position, I use with 1:1000 dilute for WB.
Date published: 2017-05-13
Rated 5 out of 5 by from The baseband is perfect.We tried it detect this sample from dilution 1:500,the baseband is perfect.
Date published: 2017-02-08
Rated 5 out of 5 by from Baseband is PerfectStAR antibody quality is very good. We tried it detect this sample from dilution 1:500. The baseband is perfect.
Date published: 2017-02-06
Rated 1 out of 5 by from did not work with porcine testis samplesWe tried this antibody (1:500) with porcine testis samples and observed no bands
Date published: 2016-12-01
Rated 5 out of 5 by from Successful application of this antibody inSuccessful application of this antibody in IP and WB using human epidermal keratinocytes (HaCaT) -SCBT Publication Review
Date published: 2015-05-03
Rated 4 out of 5 by from Worked well with transfected lysate by WBWorked well with transfected lysate by WB -SCBT QC
Date published: 2015-03-31
Rated 5 out of 5 by from IF and WB publishable data with human andIF and WB publishable data with human and rat HEK293 cells and ovary paraffin sections - SCBT Publication Review
Date published: 2015-03-03
Rated 5 out of 5 by from WB publishable data with mouse testesWB publishable data with mouse testes - SCBT Publication Review
Date published: 2015-01-07
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StAR抗体 (D-2) is rated 4.4 out of 5 by 9.
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