SPHK 1 Inhibitor 5C CAS: 120005-55-2
MF: C26H45NO4
MW: 435.64
A selective inhibitor of SphK1.

SPHK 1 Inhibitor 5C (CAS 120005-55-2)

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备用名: SKI 5C; CAY10621
应用; SPHK 1 Inhibitor 5C is a selective inhibitor of SphK1
CAS号码: 120005-55-2
纯度: ≥98%
分子量: 435.64
分子式: C26H45NO4
补充资料: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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SPHK 1 Inhibitor 5C is a selective inhibitor of SphK1, both in vitro (IC50 = 3.3 μM) and in U937 cells overexpressing human SphK1 (70% inhibition at 5 μM). The sphingosine kinases (SphK) phosphorylate sphingosine, producing the important lipid mediator sphingosine-1-phosphate (S1P). The two known kinases, SphK1 and SphK2, have different developmental and tissue expression patterns, suggesting that they have distinct physiological functions. Notably, SphK1 is overexpressed in several forms of cancer and inhibition of SphK1 inhibits tumor growth. It has no inhibitory effect on SphK2 either in vitro or in cells. Similarly, this chemical does not reduce the activity of protein kinase C (PKC) except at very high concentration (>75 μM).


参考文献

1. Spiegel, S. and Milstien, S. 2007. J. Biol. Chem. 282: 2125-2129. PMID: 17135245
2. Takabe, K., et al. 2008. Pharmacol. Rev. 60: 181-195. PMID: 18552276
3. Shida, D., et al. 2008. Curr Drug Targets. 9: 662-673. PMID: 18691013
4. Wong, L., et al. 2009. J. Med. Chem. 52: 3618-3626. PMID: 19469544

规划 :
A solution in methyl acetate
物理状态 :
Liquid
溶解度 :
Soluble in ethanol (~2 mg/ml), DMSO (~2 mg/ml), and DMF (~2 mg/ml).
保存 :
Store at -20° C
沸点 :
57° C
折射率 :
n20D 1.48 (Predicted)
IC50 :
SphK1: IC50 = 3.3 µM (human)
Ki 数据 :
SphK1: Ki= 3 µM (human)
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
运输 :
UN 1231, Class 3, Packing group II
PubChem CID :
MDL 号码 :
MFCD18428021
SMILES :
CCCCCCCCCCCCCC#CC(=O)[[email protected]@H]1COC(N1C(=O)OC(C)(C)C)(C)C

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PMID: # 33761358  Wurster, S.|Ruiz, OE.|Samms, KM.|Tatara, AM.|Albert, ND.|Kahan, PH.|Nguyen, AT.|Mikos, AG.|Kontoyiannis, DP.|Eisenhoffer, GT.| et al. 2021. Cell Rep. 34: 108896.

PMID: # 29805524  Zhao, Z.|Ma, J.|Hu, B.|Zhang, Y.|Wang, S.| et al. 2018. Exp Ther Med. 15: 5007-5016.

PMID: # 30317247  Wang, S.|Zhang, Q.|Wang, Y.|You, B.|Meng, Q.|Zhang, S.|Li, X.|Ge, Z.| et al. 2018. Med Sci Monit. 24: 7322-7328.

PMID: # 30575912  Eur Rev Med Pharmacol Sci. 8722-8730.

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