Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Simian immunodeficiency virus (SIV) is a retrovirus found amongst primates consisting of multiple strains. In humans, these strains are HIV-1 and HIV-2. HIV-1 is most closely related to the chimpanzee strain SIVcpz. Negative factor (Nef), also called F-protein, is an early protein that functions in optimizing the host cell environment for the replication of virions while preventing apoptosis via inhibition of the Fas and TNFR-mediated death signals and decreasing p53 half-life. The N-terminus of Nef contains myristolation sites which, upon activation, function to anchor the protein on the cytoplasmic side of the plasma membrane. SIV-1 Nef functions as a homodimer that interacts with a variety of proteins including PI 3-kinase. This interaction activates PAK2 and increases production of SIV. SIV-1 Nef plays a role in immune system evasion by down-regulating MHC-I molecules and decreasing CD4 antigens on the cellular surface.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.