RK-682 CAS: 332131-32-5
MF: (C21H35O5)2•Ca
MW: 775.06
A specific PTP1B inhibitor.

RK-682 (CAS 332131-32-5)

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应用; RK-682 is a specific PTP1B inhibitor
CAS号码: 332131-32-5
纯度: >95%
分子量: 775.06
分子式: (C21H35O5)2•Ca
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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RK-682 is the calcium salt of 3-hexadecanoyl-5-hydroxymethyl-tetronic acid, a naturally-occurring specific inhibitor of protein tyrosine phosphatase (PTPase). specifically PTP1B. RK-682 is reported to inhibit dephosphorylation activity of CD45 (IC50 = 54 microM) and VHR (IC50 = 2.0 microM), and to arrest cell cycle progress at the G1/S transition. Studies with RK-682 and derivatives have demonstrated efficacy in inhibiting HIV-1 protease activity. RK-682 also displays activity against heparanase function, a protein indicated as operative in tumor cell invasion and angiogenesis.


参考文献

1. Roggo, B.E., et al. 1994. J. Antibiot. 47: 136-142. PMID: 8150707
2. Hamaguchi, T., et al. 1995. FEBS Lett. 372: 54-58. PMID: 7556642
3. Ishida, K., et al. 2004. Mol. Cancer Ther. 3: 1069-1077. PMID: 15367701

物理状态 :
Solid
来源于 :
Streptomyces sp.
溶解度 :
Soluble in ethanol, methanol, DMF, and DMSO.
保存 :
Store at -20° C
IC50 :
CD45 dephosphorylation activity: IC50 = 54 mM; VHR dephosphorylation activity: IC50 = 2 mM
仅供科研使用。不可用于诊断或治疗。

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PMID: # 16545563  Na, M. et al. 2006. Bioorg. Med. Chem. Lett. 16: 3061-3064.

PMID: # 15367701  Ishida, K. et al. 2004. Mol. Cancer Ther. 3: 1069-1077.

PMID: # 7556642  Hamaguchi, T. et al. 1995. FEBS Lett. 372: 54-58.

PMID: # 7783960  Fujii, S. et al. 1995. Neurosci. Lett. 187: 133-136.

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