Reveromycin C CAS: 144860-69-5
MF: C37H54O11
MW: 674.8
An antibiotic inhibitor of mitogenic activity in response to EGF.

Reveromycin C (CAS 144860-69-5)

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应用; Reveromycin C is an antibiotic inhibitor of mitogenic activity in response to EGF
CAS号码: 144860-69-5
纯度: >95%
分子量: 674.8
分子式: C37H54O11
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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Reveromycin C is a natural product antibiotic isolated from Streptomyces culture broths along with Reveromycins A (sc-202314), B (sc-202315), and D (sc-202317). Reveromycin C is described to inhibit mitogenic activity in response to epidermal growth factor (EGF) with potency comparable to Reveromycins A and D (IC50 = 0.7~1.1 μg/ml) in Balb/MK cells. Inhibition of EGF function by Reveromycins is correlated to an antiproliferative effect.


参考文献

1. Takahashi, H., et al. 1992. J. Antibiot. 45: 1409-1413. PMID: 1429225
2. Takahashi, H., et al. 1992. J. Antibiot. 45: 1414-1419. PMID: 1429226
3. Miyamoto, Y., et al. 2002. J. Biol. Chem. 277: 28810-28814. PMID: 12050165

物理状态 :
Solid
来源于 :
Streptomyces sp.
溶解度 :
Soluble in methanol, ethanol, water (poor), DMF, and DMSO.
保存 :
Store at -20° C
沸点 :
851.31° C at 760 mmHg (Predicted)
密度 :
1.21 g/cm3 (Predicted)
折射率 :
n20D 1.56 (Predicted)
仅供科研使用。不可用于诊断或治疗。
MDL 号码 :
MFCD08061899
SMILES :
CC(C)CCC1(CCC2(CCC(C)C(C/C=C(\\C)/C=C/C(O)C(C)/C=C/C(=O)O)O2)OC1/C=C/C(=C/C( =O)O)/C)OC(=O)CCC(=O)O

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