Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
RECK Antibody (G-4) is a high quality monoclonal RECK antibody (also designated RECK antibody) suitable for the detection of the RECK protein of mouse, rat and human origin. RECK Antibody (G-4) is available as both the non-conjugated anti-RECK antibody form, as well as multiple conjugated forms of anti-RECK antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. RECK (reversion-inducing-cysteine-rich protein with Kazal motifs) is a membrane anchored glycoprotein that binds to and inhibits the proteolytic activity of matrix metalloproteinase-9 (MMP-9). The enzymatic activity of MMP-9 facilitates tumor invasion by proteolytically digesting the extracellular matrix, thereby enabling tumor growth, expansion and metastasis. RECK inhibits the secretion and activation of MMP-9 into the extracellular matrix, which results in the inhibition of tumor growth. RECK contains multiple EGF-like repeats and serine-protease inhibitor-like domains. The expression of RECK is suppressed in several tumors and oncogenically transformed cells, suggesting that the loss of RECK activity correlates with transformed phenotypes. Transcriptional activation of RECK is potentially negatively regulated by the Sp1 family of transcription factors, as it contains two Sp1 binding motifs in the promoter region, and, in cells transformed with the ras oncogene, the Sp1 promoter region is essential for repressing RECK gene expression.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences