RANTES Antibody (E-2): sc-373983
- RANTES Antibody (E-2) is a mouse monoclonal IgM κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 65-91 at the C-terminus of RANTES of human origin
- recommended for detection of RANTES of mouse, rat and human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for RANTES Antibody (E-2). This work is in progress.
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RANTES Antibody (E-2) is a mouse monoclonal IgM antibody that detects RANTES in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). RANTES, also known as regulated upon activation, normal T cell expressed and secreted, plays a crucial role in the immune response by acting as a potent chemoattractant for various immune cells, including monocytes and natural killer cells. RANTES is primarily expressed by platelets, eosinophils, fibroblasts, macrophages, endothelial cells, and T lymphocytes, highlighting RANTES′s importance in mediating inflammatory responses and recruiting immune cells to sites of infection or injury. Notably, RANTES is characterized by a unique structure that includes a set of conserved cysteine residues, which are essential for stability and function. The presence of these cysteines allows for the formation of disulfide bonds, contributing to RANTES′s three-dimensional conformation and ability to interact with specific receptors on target cells. Understanding the structural features of RANTES is vital, as these features directly influence biological activity and role in various physiological and pathological processes, including asthma, HIV infection, and other inflammatory diseases. Anti-RANTES antibody (E-2) is an invaluable tool for researchers studying these complex immune mechanisms and the therapeutic potential of targeting RANTES in disease.
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RANTES Antibody (E-2) References:
- Rantes activates Jak2 and Jak3 to regulate engagement of multiple signaling pathways in T cells. | Wong, M., et al. 2001. J Biol Chem. 276: 11427-31. PMID: 11278738
- RANTES stimulates inflammatory cascades and receptor modulation in murine astrocytes. | Luo, Y., et al. 2002. Glia. 39: 19-30. PMID: 12112372
- Relationship between RANTES and dendritic cells in ovarian cancer patients. | Wertel, I., et al. 2011. Front Biosci (Elite Ed). 3: 227-32. PMID: 21196302
- Rantes/Ccl5 influences hematopoietic stem cell subtypes and causes myeloid skewing. | Ergen, AV., et al. 2012. Blood. 119: 2500-9. PMID: 22289892
- Simvastatin suppresses RANTES-mediated neutrophilia in polyinosinic-polycytidylic acid-induced pneumonia. | Lee, CS., et al. 2013. Eur Respir J. 41: 1147-56. PMID: 22835616
- Interactions of the Chemokine CCL5/RANTES with Medium-Sized Chondroitin Sulfate Ligands. | Deshauer, C., et al. 2015. Structure. 23: 1066-77. PMID: 25982530
- Factors Associated with RANTES Concentration in Cardiovascular Disease Patients. | Koper-Lenkiewicz, OM., et al. 2019. Biomed Res Int. 2019: 3026453. PMID: 31396527
- Retinopathy severity correlates with RANTES concentrations and CCR 5-positive microvesicles in diabetes. | Tokarz, A., et al. 2019. Folia Med Cracov. 59: 95-112. PMID: 31891363
- RANTES/CCL5 Signaling from Jawbone Cavitations to Epistemology of Multiple Sclerosis - Research and Case Studies. | Lechner, J., et al. 2021. Degener Neurol Neuromuscul Dis. 11: 41-50. PMID: 34262389
- Effect of Neurokinin-1 Receptor Knockdown on the Expression of RANTES in Allergic Rhinitis. | Wang, H., et al. 2023. Am J Rhinol Allergy. 37: 730-738. PMID: 37525517
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RANTES Antibody (E-2) | sc-373983 | 200 µg/ml | $322.00 | |||
RANTES (E-2) Neutralizing Peptide | sc-373983 P | 100 µg/0.5 ml | $69.00 |