RANTES Antibody (5): sc-101501

RANTES Antibody (5) is a mouse monoclonal IgG1 antibody that detects RANTES in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). RANTES, also known as regulated upon activation, normal T cell expressed and secreted, plays a crucial role in the immune response by acting as a potent chemoattractant for various immune cells, including monocytes and natural killer cells. RANTES is primarily secreted by platelets, eosinophils, fibroblasts, macrophages, endothelial cells, and T lymphocytes, highlighting RANTES′s importance in mediating inflammatory responses and recruiting immune cells to sites of infection or injury. Notably, RANTES is characterized by a unique structure that includes a set of conserved cysteine residues, which are essential for stability and function. The presence of these cysteines allows for the formation of disulfide bonds, contributing to RANTES′s three-dimensional conformation and ability to interact with specific receptors on target cells. Understanding the structural features of RANTES is vital, as these features directly influence biological activity and the subsequent immune response. Anti-RANTES antibody (5) is an invaluable tool for researchers studying immune cell dynamics and the underlying mechanisms of inflammation.

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RANTES Antibody (5) References:

1. Rantes production during development of cardiac allograft vasculopathy.  |  Yun, JJ., et al. 2001. Transplantation. 71: 1649-56. PMID: 11435978
2. RANTES-induced chemokine cascade in dendritic cells.  |  Fischer, FR., et al. 2001. J Immunol. 167: 1637-43. PMID: 11466387
3. Oligomerized, filamentous surface presentation of RANTES/CCL5 on vascular endothelial cells.  |  Øynebråten, I., et al. 2015. Sci Rep. 5: 9261. PMID: 25791723
4. Peripheral Neuropathic Facial/Trigeminal Pain and RANTES/CCL5 in Jawbone Cavitation.  |  Lechner, J. and von Baehr, V. 2015. Evid Based Complement Alternat Med. 2015: 582520. PMID: 26170877
5. RANTES and SDF-1 Are Keys in Cell-based Therapy of TMJ Osteoarthritis.  |  Lu, L., et al. 2015. J Dent Res. 94: 1601-9. PMID: 26377571
6. RANTES Gene Polymorphisms Associated with HIV-1 Infections in Kenyan Population.  |  Mutuiri, SP., et al. 2016. Dis Markers. 2016: 4703854. PMID: 27821902
7. CCL5/RANTES contributes to hypothalamic insulin signaling for systemic insulin responsiveness through CCR5.  |  Chou, SY., et al. 2016. Sci Rep. 6: 37659. PMID: 27898058
8. IP-10 and RANTES as biomarkers for pulmonary tuberculosis diagnosis and monitoring.  |  Zhao, Y., et al. 2018. Tuberculosis (Edinb). 111: 45-53. PMID: 30029914
9. The Involvement of the Chemokine RANTES in Regulating Luminal Acidification in Rat Epididymis.  |  Feng, X., et al. 2020. Front Immunol. 11: 583274. PMID: 33072131
10. RANTES chemokine expression in diseased and normal human tissues.  |  von Luettichau, I., et al. 1996. Cytokine. 8: 89-98. PMID: 8742071

The preferred RANTES antibody is RANTES Antibody (A-4): sc-365826.