(R)-(-)-Phenylephrine hydrochloride CAS: 61-76-7
MF: C9H13NO2 HCl
MW: 203.67
An α1-adrenoceptor agonist.

(R)-(-)-Phenylephrine hydrochloride (CAS 61-76-7)

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备用名: (R)-(-)-1-(3-Hydroxyphenyl)-2-methylaminoethanol hydrochloride
应用; (R)-(−)-Phenylephrine hydrochloride is an α1-adrenoceptor agonist
CAS号码: 61-76-7
分子量: 203.67
分子式: C9H13NO2 HCl
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).

(R)-(-)-Phenylephrine hydrochloride is a phenylephrine (PE) and an α1-adrenoceptor agonist that promotes hypertrophic growth in the ventricular myocytes, and activates several MAPK signaling pathways. (R)-(-)-Phenylephrine hydrochloride is an activator of α1A-AR, α1D-AR and α1B-AR.


参考文献

1. Minneman, K.P., et al. 1994. Mol. Pharmacol. 46: 929-936. PMID: 7969082
2. Ford, A.P., et al. 1997. Br. J. Pharmacol. 121: 1127-1135. PMID: 9249248
3. Lazou, A., et al. 1998. Biochem. J. 332: 459-465. PMID: 9601075
4. Hattori, Y. and Kanno, M. 1998. Life Sci. 62: 1449-1453. PMID: 9585117
5. Eckert, R.E., et al. 2000. Urol. Res. 28: 122-127. PMID: 10850635
6. Morton, J.S., et al. 2007. Br. J. Pharmacol. 150: 112-120. PMID: 17115072

外观 :
Crystalline powder
物理状态 :
Solid
溶解度 :
Soluble in water (100 mM), DMSO (100 mM), alcohol, methanol, and ethanol (41 mg/ml at 25° C).
保存 :
Store at room temperature
熔点 :
143-145° C (lit.)
沸点 :
341.1° C at 760 mmHg (Predicted)
折射率 :
n20D 1.57 (Predicted)
光学活性 :
α20/D -43.9°, c = 2 in water; α20/D -51.5°, c = 2 in ethanol; α20/D -45.5°±1.5°, c = 1 in water
IC50 :
Adrenergic receptor α-2: IC50 = 78 nM (rat); Adrenergic receptor α-1: IC50 = 2 µM (rat); Serotonin 2a receptor: EC5050 = 19.26 µM (rat); MOR-1: EC5050 = 92.43 µM (human)
Ki 数据 :
Adrenergic receptor α-2: Ki= 270 nM (rat); Adrenergic receptor α-2: Ki= 390 nM (human); Adrenergic receptor α-1: Ki= 6.1 µM (rat); Β-1 adrenergic receptor: Ki= 13 µM (rat); Adrenergic receptor β ADRB1 & ADRB3: Ki= 13 µM (human)
pK值 :
pKa: 8.86
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
RTECS :
DO7525000
PubChem CID :
默克索引 :
14: 7286
MDL 号码 :
MFCD00012605
EC号码 :
200-517-3
Beilstein 注册 :
4158948
SMILES :
Cl.CNC[[email protected]](O)C1=CC(O)=CC=C1

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PMID: # 32890729  Mol. Cell. Neurosci. 103550.

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