Pyrimethamine CAS: 58-14-0
MF: C12H13ClN4
MW: 248.71
An inhibitor of P-glycoprotein and DHFR.

Pyrimethamine (CAS 58-14-0)

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备用名: 5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine; Daraprim
应用; Pyrimethamine is an inhibitor of P-glycoprotein and DHFR
CAS号码: 58-14-0
纯度: ≥95%
分子量: 248.71
分子式: C12H13ClN4
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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Pyrimethamine is a potent inhibitor of multi-drug and toxin extrusion transporters. This compound inhibits Mdr-1(P-glycoprotein) and thus allows for active drugs to stay within the cell for longer periods of time, increasing their effectiveness by preventing efflux of the active compound from the cytoplasm. Pyrimethamine also inhibits DHFR(dihydrofolate reductase ).


参考文献

Loutfy, M.A., et al.: Anal. Profiles Drug Subs., 12, 463 (1983), Leport, C., et al.: Am. J. Med., 84, 94 (1988), McIntosh, H.M., et al.: Ann. Trop. Med., Parasitol., 93, 265 (1998), Plowe, C.V., et al.: Br. Med. J., 328, 545 (2004),

物理状态 :
Solid
溶解度 :
Soluble in Ethanol (hot)
保存 :
Store at -20° C
熔点 :
233-2340°C (lit.)
沸点 :
368.4° C at 760 mmHg
密度 :
~1.4 g/cm3 (Predicted)
仅供科研使用。不可用于诊断或治疗。
PubChem CID :
SMILES :
CCC1=C(C(=NC(=N1)N)N)C2=CC=C(C=C2)Cl

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PMID: # 34193287  Sina, S.|Mohammad, JM.|Reza, S.|Anita, M.|Soudabeh, E.|Hadi, M.| et al. 2021. Eur J Med Res. 26: 65.

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