Prostaglandin D2 methyl ester CAS: 49852-81-5
MF: C21H34O5
MW: 366.49
A lipid-soluble, cell-permeable PGD2 analog.

Prostaglandin D2 methyl ester (CAS 49852-81-5)

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备用名: PGD2 methyl ester
应用; Prostaglandin D2 methyl ester is a lipid-soluble, cell-permeable PGD2 analog
CAS号码: 49852-81-5
分子量: 366.49
分子式: C21H34O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Prostaglandin D2 methyl ester is a more lipid-soluble, cell-permeable prodrug form of prostaglandin D2 (PGD2). Studies have shown that it has a 5-10 fold lower affinity for PGD2 receptors than PGD2.


参考文献

1. Hayaishi, O., et al., 1988. Sleep-wake regulation by prostaglandins D2 and E2. The Journal of biological chemistry. 263(29): 14593-6. PMID: 3049580
2. Onoe, H., et al., 1988. Prostaglandin D2, a cerebral sleep-inducing substance in monkeys. Proceedings of the National Academy of Sciences of the United States of America. 85(11): 4082-6. PMID: 3163802
3. Giles, H., et al., 1988. The biology and pharmacology of PGD2. Prostaglandins. 35(2): 277-300. PMID: 3283848
4. Suzuki, F., et al., 1987. Methyl ester of prostaglandin D2 as a delivery system of prostaglandin D2 into brain. Biochimica et biophysica acta. 917(2): 224-30. PMID: 3467795
5. Li, Jianjun., et al., 2003. The ethanol metabolite, linolenic acid ethyl ester, stimulates mitogen-activated protein kinase and cyclin signaling in hepatic stellate cells. Life sciences. 73(9): 1083-96. PMID: 12818718
6. Hirai, Hiroyuki., et al., 2003. Gene structure and functional properties of mouse CRTH2, a prostaglandin D2 receptor. Biochemical and biophysical research communications. 307(4): 797-802. PMID: 12878180

规划 :
A solution in methyl acetate
物理状态 :
Liquid
保存 :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
SMILES :
CCCCC[[email protected]@H](/C=C/[[email protected]@H]1[[email protected]]([[email protected]](CC1=O)O)C/C=C\CCCC(=O)OC)O

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