m-IgGκ BP-HRP (mouse IgGκ binding protein-HRP) is the preferred detection reagent for Properdin Antibody (D-3) for WB applications. This reagent is now offered in a bundle with Properdin Antibody (D-3) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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Properdin Antibody (D-3) is a high quality monoclonal Properdin antibody (also designated Properdin antibody) suitable for the detection of the Properdin protein of mouse origin. Properdin Antibody (D-3) is available as both the non-conjugated anti-Properdin antibody form, as well as multiple conjugated forms of anti-Properdin antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The serum complement system (SCS), containing over 30 glycoproteins, influences physiological mechanisms of the body in response to immune complex (the classical pathway), carbohydrate (the lectin pathway) or bacterial (alternative pathway) initiation. Properdin, also known as complement factor P (CFP), PFC, BFP or PFD, is a secreted glycoprotein that participates in positively regulating the alternative pathway of the SCS. Properdin exists as a cyclic polymer with six Thrombospondin type-1 domains and binds to C3 and C5 convertase complexes (C3bBb and (C3b)nBb) functioning to assist in their stabilization. Properdin is also required for the deposition of C3b onto the surface of pathogens. Mutations in the gene encoding Properdin can result in Properdin deficiency (PFD), a disease characterized by higher susceptibility to bacterial infections.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
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Are there any issues with using sc-393723: Properdin (D-3) mouse monoclonal primary antibody on mouse samples?
Asked by: Dr Ninau Qelp
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent,we recommend using a directly conjugated primary antibody. Please contact our special orders department for pricing and availability of sc-393723 conjugates.