PPQ-102 CAS: 931706-15-9
MF: C26H22N4O3
MW: 438.48
A cell-permeable inhibitor of CFTR- mediated chloride currents.

PPQ-102 (CAS 931706-15-9)

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备用名: CFTR Inhibitor IV
应用; PPQ-102 is a cell-permeable inhibitor of CFTR- mediated chloride currents
CAS号码: 931706-15-9
纯度: ≥95%
分子量: 438.48
分子式: C26H22N4O3
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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CFTR Inhibitor IV, PPQ-102 is a compound that targets intracellular nucleotide binding domain(s) of CFTR and inhibits CFTR- mediated chloride current in a voltage-dependent and reversible manner. CFTR Inhibitor IV, PPQ-102 is a cell-permeable pyrimido-pyrrolo-quinoxalinedione (PPQ) and in studies has shown that the nature of PPQ-102 inhibition is due to a stabilization of the channels in a closed state.

外观 :
Crystalline
物理状态 :
Solid
溶解度 :
Soluble in DMSO (5 mg/ml).
保存 :
Store at -20° C
熔点 :
244-246° C
沸点 :
~648.7° C at 760 mmHg (Predicted)
密度 :
~1.4 g/cm3 (Predicted)
折射率 :
n20D 1.72 (Predicted)
IC50 :
CFTR: IC50 = 90 nM (human)
pK值 :
pKb: 1 (Predicted)
仅供科研使用。不可用于诊断或治疗。
PubChem CID :
MDL 号码 :
MFCD14824240
SMILES :
CC1=CC=C(O1)C2C3=C4C(=C(N3C5=CC=CC=C5N2)C6=CC=CC=C6)C(=O)N(C(=O)N4C)C

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PMID: # 27827428  Fujii, S. et al. 2016. Sci Rep. 6: 36795.

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