PPIase-Parvulin 抑制剂 CAS: 64005-90-9
MF: C22H18N2O8
MW: 438.4
A Pin1/Pin4 PPIase activity inhibitor.

PPIase-Parvulin 抑制剂 (CAS 64005-90-9)

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备用名: PiB; HIC 016C; Diethyl-1,3,6,8-tetrahydro-1,3,6,8-tetraoxobenzo[lmn][3,8]phenanthroline-2,7-diacetate
应用; PPIase-Parvulin Inhibitor is a Pin1/Pin4 PPIase activity inhibitor
CAS号码: 64005-90-9
纯度: ≥95%
分子量: 438.4
分子式: C22H18N2O8
补充资料: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).

PPIase-Parvulin Inhibitor is a cell-permeable napthalenetetracarboxylic-bisimide compound that displays anti-proliferative properties. PPIase-Parvulin Inhibitor causes cell cycle arrest and acts as a potent, competitive, selective, reversible, active site binding inhibitor of Pin1/Pin4 PPIase (peptidyl prolyl cis-trans isomerase) activity. It does not bind to DNA or functions as a topoisomerase I inhibitor.


参考文献

1. Uchida, Takafumi., et al., 2003. Pin1 and Par14 peptidyl prolyl isomerase inhibitors block cell proliferation. Chemistry & biology. 10(1): 15-24. PMID: 12573694

物理状态 :
Solid
溶解度 :
Soluble in chloroform (1 mg/ml), and ethanol (250 µg/ml, cloudy suspension).
保存 :
Store at 4° C
熔点 :
>300° C
沸点 :
636.46° C at 760 mmHg (Predicted)
密度 :
1.47 g/cm3 (Predicted)
折射率 :
n20D 1.64 (Predicted)
IC50 :
Pin1/Par14 PPIase : IC50 = ~ 1.5 µM
仅供科研使用。不可用于诊断或治疗。
运输 :
UN 3077, Class 9, Packing group III
PubChem CID :
SMILES :
CCOC(=O)CN1C(=O)C2=C3C(=CC=C4C3=C(C=C2)C(=O)N(C4=O)CC(=O)OCC)C1=O

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