Date published: 2026-10-16

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PP2A-Cα/β 抗体 (G-4): sc-166034

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说明书
  • PP2A-Cα/β抗体(G-4)是小鼠单克隆IgG1 κ, 在6篇文献中引用,规格为200 µg/ml
  • 特异性抗原位于human物种的PP2A-Cα/β的C-terminus的氨基酸275-309之间
  • 推荐用于 mouse, rat, human 和 来源的PP2A-Cα/β WB, IP, IF, IHC(P) 和 ELISA检测; 也和以下物种反应,包括: 和 equine, canine, bovine, porcine and avian
  • 看 PP2A-Cα/β (1D6): sc-80665,可查看有标记的 PP2A-Cα/β 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • 1 BP-HRP">m-IgG1 BP-HRP和m-IgGκ BP-HRP是PP2A-Cα/β Antibody (G-4) 适用于 WB 和 IHC(P) 应用。 的首选辅助检测试剂。这些试剂现与PP2A-Cα/β Antibody (G-4) 打包提供(请参阅下面的订购信息)。
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関連項目

在真核生物中,丝氨酸和苏氨酸残基上的蛋白质磷酸化和去磷酸化是调节广泛细胞功能的重要手段,包括细胞分裂、稳态和凋亡。密切参与这一过程的一组蛋白质是蛋白质磷酸酶。通常,蛋白质磷酸酶(PP)全酶是由调节亚基、可变亚基和催化亚基组成的三聚体复合物。已经鉴定出四种主要的蛋白质磷酸酶催化亚基家族,称为PP1、PP2A、PP2B(钙调神经磷酸酶)和PP2C。另外一种蛋白质磷酸酶催化亚基PPX(也称为PP4)是一个新型PP家族的假定成员。PP2A家族包括亚家族成员PP2Aα和PP2Aβ。PP2A催化亚基与多种调节亚基相关联。调节亚基包括PP2A-Aα和PP2A-Aβ、PP2A-Bα和PP2A-Bβ、PP2A-Cα和PP2A-Cβ以及PP2A-B56α和PP2A-B56β。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

PP2A-Cα/β 抗体 (G-4) 参考文献:

  1. 磷酸酶:PP2A的结构重要性、调节及其在癌症中的异常表达。  |  Seshacharyulu, P., et al. 2013. Cancer Lett. 335: 9-18. PMID: 23454242
  2. 心脏中蛋白磷酸酶2A(PP2A)的作用和调节。  |  Lubbers, ER. and Mohler, PJ. 2016. J Mol Cell Cardiol. 101: 127-133. PMID: 27832939
  3. 甲基化调节的多聚体PP2A复合物的退役。  |  Wu, CG., et al. 2017. Nat Commun. 8: 2272. PMID: 29273778
  4. 蛋白磷酸酶2A(PP2A)在癌症中的非基因组调控机制。  |  Kauko, O. and Westermarck, J. 2018. Int J Biochem Cell Biol. 96: 157-164. PMID: 29355757
  5. 聚胞素-1 通过磷酸酶 PP2A/B56α 抑制细胞增殖  |  Tang, Y., et al. 2019. Biomed Res Int. 2019: 2582401. PMID: 31641668
  6. 酵母细胞有丝分裂和细胞分裂过程中的PP2A功能。  |  Moyano-Rodriguez, Y. and Queralt, E. 2019. Int J Mol Sci. 21: PMID: 31906018
  7. 类似 PP2A 的蛋白磷酸酶在调控减数分裂进程中的关键功能》(Critical Functions of PP2A-Like Protein Phosphotases in Regulating Meiotic Progress.  |  Lei, WL., et al. 2021. Front Cell Dev Biol. 9: 638559. PMID: 33718377
  8. 在 MC3T3-E1 细胞中,NXNL1 通过 GDF15 诱导的 PP2A Cα 依赖性方式负向调节成骨细胞分化。  |  Kim, KM. and Jang, WG. 2022. Biofactors. 48: 239-248. PMID: 34932831
  9. 鉴定PP2A-B55靶标揭示了果蝇核膜重组过程中对EMERIN的调控。  |  Emond-Fraser, V., et al. 2023. Open Biol. 13: 230104. PMID: 37463656
  10. Corynoxine通过激活PP2A和调节NSCLC中的AKT-mTOR/GSK3β轴来触发细胞死亡。  |  Hou, G., et al. 2024. Biochem Pharmacol. 222: 116110. PMID: 38460908

订购信息

产品名称产品编号规格价格数量收藏夹

PP2A-Cα/β 抗体 (G-4)

sc-166034
200 µg/ml
$322.00

PP2A-Cα/β (G-4): m-IgGκ BP-HRP 套装

sc-534694
200 µg Ab; 40 µg BP
$361.00

PP2A-Cα/β (G-4): m-IgG1 BP-HRP 套装

sc-538873
200 µg Ab; 20 µg BP
$361.00

PP2A-Cα/β (G-4) 中和勝肽

sc-166034 P
100 µg/0.5 ml
$69.00

What application is the blocking peptide sc-166034 P appropriate for?

Asked by: Germaine
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by Yin from Worked great in WBWorked great in WB, strong band at 1:200 dilution.
Date published: 2015-10-16
Rated 5 out of 5 by NZ from Good publishable data in WB in human HeLa cellsGood publishable data in WB in human HeLa cells. -SCBT Publication Review
Date published: 2015-04-02
Rated 5 out of 5 by FL from Produced beautiful immunoperoxidase cytoplasmicProduced beautiful immunoperoxidase cytoplasmic staining in formalin fixed, paraffin-embedded human pancreas tissue. -SCBT QC
Date published: 2015-03-21
Rated 5 out of 5 by CJ from Robust signal in WB in human transfectedRobust signal in WB in human transfected 293T and MCF7 whole cell lysates. -SCBT QC
Date published: 2015-03-18
Rated 5 out of 5 by LF from Strong pull down in IP in mouse Primary neuronalStrong pull down in IP in mouse Primary neuronal cell. -SCBT Publication Review
Date published: 2015-02-12
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PP2A-Cα/β 抗体 (G-4) is rated 5.0 out of 5 by 5.
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