Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
The plasma membrane Ca2+-pumping ATPase (PMCA) mRNAs are encoded on four genes designated PMCA1-4. The PMCA genes undergo alternative splicing to yield "b" splice forms, which contain PDZ interaction domains and interact promiscuously but also specifically with different members of the PSD95 family. PMCA4b is the major PMCA expressed in developing mammary tissue. During lactation, PMCA1b expression increases while PMCA4b expression decreases, indicating that PMCAs play a critical role in maintaining cellular Ca2+ homeostasis. In addition, human PMCA4b may have an important role in regulating intracellular Ca2+ in the apoptotic cell. PMCA4b is cleaved at Asp 1080 by caspase-3 to produce a single fragment that is fully active, responding much faster to an increase in Ca2+ than the autoinhibited form. PMCA4b also plays an essential role in maintaining low cytosolic Ca2+ in resting platelets. Specifically, PMCA4b is phosphorylated on Tyr 1176 by pp60 (src).
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.